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Clinical Research Training Fellowship in Diabetes at the University of Edinburgh "Can Automated Insulin Delivery (AID) Restore Glucagon Secretion To Hypoglycemia in C-Peptide Negative Type 1 Diabetes"

  • Full or part time

    Prof R McCrimmon
  • Application Deadline
    Monday, July 01, 2019
  • Funded PhD Project (European/UK Students Only)
    Funded PhD Project (European/UK Students Only)

Project Description

The main aim of the project is to determine if maximising glycaemic Time in Range is sufficient to restore glucagon secretory responses to insulin-induced hypoglycaemia in people with Type 1 diabetes. Glycaemic Time in Range will be maximised in our research participants with Automated Insulin Delivery systems and participants will undergo intensive glycaemic surveillance throughout the study period. Hypoglycaemic clamp studies will be performed at baseline and at time intervals post intervention and circulating glucagon responses to hypoglycaemia measured. A finding of increased circulating glucagon responses to hypoglycaemia following a period of increased glycaemic Time in Range, would indicate that this defect may be partially/fully reversed with this intervention.

Supervision and Location of Study
This fully funded Clinical PhD Studentship will be jointly supervised by Dr Shareen Forbes (Principal Supervisor, University of Edinburgh) and Professor Rory McCrimmon (2nd Supervisor, University of Dundee). The research is supported by a Clinical Research Nurse funded specifically for this study and benefits from additional support and funding from industry. The research will be based at the Centre for Cardiovascular Sciences at the University of Edinburgh. The Centre is based within the Edinburgh Medical School in the outstanding facilities of the Queen’s Medical Research Institute at the site of the Royal Infirmary of Edinburgh hospital.

Funding Notes

The successful applicant will be awarded a three year Clinical Research Training Fellowship funded by the Helmsley Foundation, commencing either August 1st 2019 or February 1st 2020. Includes their stipend and tuition fees at the UK/EU rate and research consumables for their PhD project.

The studentship will be awarded competitively.

You should apply for this via the Edinburgh University jobs website. The Job Vacancy number is 048161


Applicants should also arrange for two academic referees to submit letters of reference. Please ensure this is added to your application via the jobs Edinburgh University jobs webstie. Vacancy reference number 048161

Informal queries relating to this post should be sent to Shareen Forbes, [email protected]

All formal applications should be completed through the University of Edinburgh jobs website, otherwise you cannot be considered for the post.

Related Subjects

How good is research at University of Edinburgh in Clinical Medicine?

FTE Category A staff submitted: 206.93

Research output data provided by the Research Excellence Framework (REF)

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