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Clostridium difficile in Australian horse populations

  • Full or part time
  • Application Deadline
    Saturday, May 30, 2020
  • Funded PhD Project (Students Worldwide)
    Funded PhD Project (Students Worldwide)

About This PhD Project

Project Description

The anaerobic spore-forming bacterium Clostridium difficile is a major human pathogen, the most commonly diagnosed cause of infectious hospital diarrhoea. Toxigenic isolates of C. difficile usually produce two toxins, A and B, and these are thought of as the major virulence factors. C. difficile is also a known cause of diarrhoea, necrotizing enteritis and death in horses. As with humans, predisposing factors for infection include hospitalisation, antimicrobial use and interaction with infant animals. C. difficile in horses could potentially act as a reservoir for zoonotic spread, as well as pose a danger to horses exposed to antimicrobials. Horses occupy an interesting position in relation to C. difficile in Australia, with overlapping domains of performance, companion and wild animal. The potential for dissemination of C. difficile could encompass transfer through interaction, consumption and indirectly through exposure to horse manure. The ubiquitous nature of C. difficile makes a One Health approach vital. In humans, community-acquired C. difficile infection is increasing, and reasons for this are not well understood. Horses represent a unique animal population about which little is known in Australia. The over-arching aim of this project is to investigate the presence and characteristics of C. difficile in Australian horse populations.

If you meet the HDR admission requirements (https://www.murdoch.edu.au/study/research-students/how-to-apply) please send an e-mail directly to PRINCIPAL SUPERVISOR with following information:
- Email subject:
Please write the follow “Prospective PhD” and the title of the project you are enquiring about.

- Email body:
provide the following information;
1. Your academic & research background, experiences, and research interests.
2. When you expect to start your PhD if successful.

- Attachments:
CV and academic transcript

Applications accepted by May 30th, 2020 or until position is filled.

Related Subjects

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