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CMOS-Based Nanocapacitor Arrays

Project Description

This opportunity is part of the SENTINEL programme ( and will be based at the University of Twente in the Netherlands.

We will explore single-entity detection for biosensing using high-frequency CMOS-based nanocapacitor arrays.

Expected Results:
Biosensors that rely solely on electrical detection are highly desirable for integration with electronics on the same chip, enabling new assays based on ‘digital’ detection. Instead of measuring the average response to a large number of molecules, digital sensors aim to detect individual molecular interactions as discrete, countable events at large numbers of parallel detectors, thus achieving extreme sensitivities. An important bottleneck, however, has been the lack of a suitable method for easily converting single-entity (bio)chemical information directly into electrical signals.

Electrochemical Impedance Spectroscopy (EIS), which uses AC signals to probe the medium near an electrode, is in principle ideally suited for this purpose, but stray capacitance has largely prevented its use in nanoscale systems. We have previously demonstrated (C. Laborde et al., Nature Nanotech. 10, 791 (2015)) that this hurdle can be overcome by integrating the electrodes directly into a CMOS microelectronics chip, yielding arrays of individually addressable nanoelectrodes operated at frequencies that are orders of magnitude higher than previously possible.

In the present project, we will explore the use of this platform to develop massively parallel digital assays, with the ultimate aim of detecting and fingerprinting individual macromolecules in a label-free manner. The project is a close collaboration with industry partner NXP Semiconductors.

This position will remain open only until it is filled and therefore you should submit your application as soon as possible.

Please submit your application in PDF format to both () and (). Your application should consist of: your CV; statement about your research interests; copy of your Diploma and/or Masters Degree certificate; details for at least 3 referees.

Funding Notes

Applications are invited from candidates with a background in physics, physical chemistry, electrical engineering or a closely related discipline; strong communication skills, including fluency in written and spoken English; less than 4 years' research experience, you do not have a PhD at the employment start date; not have lived in or carried out your main activity (work or study) in the Netherlands for more than 12 months in the 3 years immediately prior to the recruitment start date.

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