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Project title: Coherent femtosecond soft X-ray microscopy
Supervisory Team: Dr Bill Brocklesby, Prof Jeremy Frey
Project description
We are looking for a student to join an exciting new project in the field of bio-imaging. The project, recently awarded funding of ~£5M, aims to use laser-generated soft X-ray radiation for coherent imaging of nanoscale biological structures. The X-ray generation process, known as high-harmonic generation, is based on nonlinear optics using extremely high-intensity femtosecond laser pulses, the topic of the 2023 Nobel Prize in Physics. The imaging process uses computational algorithms to transform the scattered X-ray patterns into detailed images with resolution of 10nm or less, comparable with electron microscopes but with the huge advantages of X-rays in looking within biological structures like cells or neurons.
The capability to generate coherent soft X-rays in a lab is limited to a few research groups worldwide. This PhD project will look at optimising X-ray generation for use in microscopy and will develop coherent imaging in the soft X-ray regime.
The student will be part of a multidisciplinary team constructing a new laser laboratory at the Rutherford Appleton Labs (RAL), home of the most powerful femtosecond lasers in the UK, and of the Rosalind Franklin Institute (RFI), the UK’s premier research institute in biological imaging. The lab will exploit a new generation of fibre-laser femtosecond sources producing high-energy pulses in the infrared at average powers 100 times higher than typical femtosecond lasers.
The candidate will join a welcoming community at Southampton, the RFI, and the Central Laser Facility of RAL, a team including physicists, chemists, computer scientists, and biologists developing imaging techniques within a supportive and diverse environment. The ideal candidate will have a background in physics, have studied nonlinear optics and/or lasers, and have an interest in computational techniques both for lab operation and data analysis. Collaboration across disciplines, from algorithm development to biology, will be essential and will provide the student with a broad background in some of the most exciting areas of photonics, and strong support for career development.
Find out more about:
Our department and research group:
https://www.southampton.ac.uk/about/faculties-schools-departments/zepler-institute
https://www.southampton.ac.uk/research/groups/ultrafast-x-ray-group
The PhD programme:
https://www.southampton.ac.uk/study/postgraduate-research/photonics-optoelectronics
https://www.youtube.com/watch?v=N2_6yNQamkU
For further details of the project please contact Dr Bill Brocklesby, [Email Address Removed]
Entry Requirements
A very good undergraduate degree (at least a UK 2:1 honours degree, or its international equivalent) in physics or a closely related discipline.
Ideally you:
Closing date
Applications are accepted throughout the year. The start date will typically be late September, but other dates are possible.
Funding
For UK students, tuition fees and a stipend at the UKRI rate plus £2,000 ORC enhancement tax-free per annum for up to 3.5 years (totalling around £21,237 for 2024/25, rising annually). EU and Horizon Europe students are eligible for scholarships. The China Scholarship Council (CSC) students are eligible for fee waivers. Funding for other international applicants is very limited and highly competitive. Overseas students who have secured or are seeking external funding are welcome to apply.
How To Apply
Apply online via clicking the 'Apply' button. Select programme type (Research), Faculty of Engineering and Physical Sciences, next page select “PhD ORC”. In Section 2 of the application form you should insert the name of the supervisor.
Applications should include:
Curriculum Vitae (CV)
Two reference letters
Degree Transcripts/Certificates to date
For further information please contact: [Email Address Removed]
For UK students, tuition fees and a stipend at the UKRI rate plus a £2,000 ORC enhancement, tax-free, per year for up to 3.5 years (for 2024/25 it will make £21,237 in total, rising annually).
EU and Horizon Europe students are eligible for scholarships.
The China Scholarship Council (CSC) students are eligible for fee waivers.
Funding for other international applicants is very limited and highly competitive. Overseas students who have secured or are seeking external funding are welcome to apply.
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