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Collaborative PhD Studentship between School of Dental Sciences and School of Pharmacy - Investigation of effects of PKCδ inhibitor rottlerin in neuropathic pain management

   Faculty of Medical Sciences Graduate School

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  Dr Seva Telezhkin, Dr Ilona Obara  No more applications being accepted  Funded PhD Project (UK Students Only)

About the Project

Number of awards


Start date and duration

September 2021 – August 2024 (3 years)


The proposed project will investigate role of PKCδ in nociceptive pathways in neuropathic pain models. The project will use in vitro cellular models (human induced pluripotent stem cell (iPSC)-derived neurons) and in vivo (rat) models. Our work will explore a novel strategy for the improvement of chronic pain that originates within the orofacial trigeminal somatosensory system and will lead to a better understanding of chronic pain pathophysiology and potentially improved therapeutic approaches targeting specific pathologies.

The student will join the laboratories of Drs Telezhkin (Dental Sciences) and Obara (Pharmacy). They will benefit from daily interactions with other PhD students in the labs who are engaged in a wide variety of pain related research and will engage with the larger Pain Research Group (~10-15 nonclinical and clinical staff and students) that holds regular meetings to discuss data, projects, articles, etc. An active engagement with the members of the group will provide the student with a breadth of experience and the opportunity to present in a supportive environment.

The student will receive training in acquiring knowledge and practical skills, i.e., stem cell culture, patch-clamp electrophysiology, in vivo testing, molecular techniques including immunocytochemistry, fluorescent microscopy and imaging as well as literature review, data analysis, data interpretation and academic writing. To obtain PIL ABC from the Home Office the student will take mandatory animal-license modules. The student will also be encouraged to present their work at conferences, both internally and nationally/internationally, and also to participate in public-engagement events to develop personal skills like communication and time management. Finally, Newcastle University offers courses and workshops for all PhD students related to career choices and the development of transferable skills.


Newcastle University, School of Dental Sciences, Tregarthan PhD Studentship

Name of supervisor(s)

Dr V Telezhkin (School of Dental Sciences), Dr I Obara (School of Pharmacy) and Prof J Durham (School of Dental Sciences)

Eligibility Criteria

UK -classified students only – Tregarthan PhD Studentship will not fund international students.

Applicants must have, or expect to achieve, at least a 2:1 Honour’s degree in biomedicine, physiology, biophysics, pharmacology or a related area.

How to apply

You must apply through the University’s online postgraduate application system by creating an account. To do this, please select ‘How to Apply’ and choose the ‘Apply now’ button.

All relevant fields should be completed. All fields marked with a red asterisk must be completed.

You will need to: 

  1. Click on programme of study
  2. Insert 8300F in the programme code section and click search
  3. Select Programme name ‘PhD in the Faculty of Medical Sciences (full time) – Neuroscience'
  4. Insert TC027 in the studentship/partnership reference field
  5. Attach a covering letter and CV. The covering letter must state the title of the studentship, quote reference code TC027 and state how your interests and experience relate to the project
  6. Attach degree transcripts and certificates and, if English is not your first language, a copy of your English language qualification. You will not be able to submit your application until you have submitted your degree transcript/s.


For informal enquiries, please contact Dr Telezhkin ([Email Address Removed]) and Dr Obara ([Email Address Removed]).

Funding Notes

The funding will cover home tuition fees, a stipend at current UK Research and Innovation rates for 3 years (clinical salaries will not be covered). Bench fees will be provided for consumables up to a maximum amount per annum.