About the Project
Number of awards
Start date and duration
September 2021 – August 2024 (3 years)
The proposed project will investigate role of PKCδ in nociceptive pathways in neuropathic pain models. The project will use in vitro cellular models (human induced pluripotent stem cell (iPSC)-derived neurons) and in vivo (rat) models. Our work will explore a novel strategy for the improvement of chronic pain that originates within the orofacial trigeminal somatosensory system and will lead to a better understanding of chronic pain pathophysiology and potentially improved therapeutic approaches targeting specific pathologies.
The student will join the laboratories of Drs Telezhkin (Dental Sciences) and Obara (Pharmacy). They will benefit from daily interactions with other PhD students in the labs who are engaged in a wide variety of pain related research and will engage with the larger Pain Research Group (~10-15 nonclinical and clinical staff and students) that holds regular meetings to discuss data, projects, articles, etc. An active engagement with the members of the group will provide the student with a breadth of experience and the opportunity to present in a supportive environment.
The student will receive training in acquiring knowledge and practical skills, i.e., stem cell culture, patch-clamp electrophysiology, in vivo testing, molecular techniques including immunocytochemistry, fluorescent microscopy and imaging as well as literature review, data analysis, data interpretation and academic writing. To obtain PIL ABC from the Home Office the student will take mandatory animal-license modules. The student will also be encouraged to present their work at conferences, both internally and nationally/internationally, and also to participate in public-engagement events to develop personal skills like communication and time management. Finally, Newcastle University offers courses and workshops for all PhD students related to career choices and the development of transferable skills.
Newcastle University, School of Dental Sciences, Tregarthan PhD Studentship
Name of supervisor(s)
Dr V Telezhkin (School of Dental Sciences), Dr I Obara (School of Pharmacy) and Prof J Durham (School of Dental Sciences)
UK -classified students only – Tregarthan PhD Studentship will not fund international students.
Applicants must have, or expect to achieve, at least a 2:1 Honour’s degree in biomedicine, physiology, biophysics, pharmacology or a related area.
How to apply
You must apply through the University’s online postgraduate application system by creating an account. To do this, please select ‘How to Apply’ and choose the ‘Apply now’ button.
All relevant fields should be completed. All fields marked with a red asterisk must be completed.
You will need to:
- Click on programme of study
- Insert 8300F in the programme code section and click search
- Select Programme name ‘PhD in the Faculty of Medical Sciences (full time) – Neuroscience'
- Insert TC027 in the studentship/partnership reference field
- Attach a covering letter and CV. The covering letter must state the title of the studentship, quote reference code TC027 and state how your interests and experience relate to the project
- Attach degree transcripts and certificates and, if English is not your first language, a copy of your English language qualification. You will not be able to submit your application until you have submitted your degree transcript/s.
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