Combatting the enemy within: intracellular immune detection of genome instability to prevent cancer at University of Edinburgh on FindAPhD.com

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Prof A Jackson No more applications being accepted Competition Funded PhD Project (European/UK Students Only)

About the Project

This is one of several projects available on an MRC funded 4-year multi-disciplinary PhD programme in Human Genetics, Genomics and Disease at the MRC Human Genetics Unit (HGU), part of the Institute of Genetics and Molecular Medicine (IGMM) at the University of Edinburgh.

Project details:

The cGAS-STING pathway senses cytoplasmic DNA to identify and combat microbial pathogens, while strict compartmentalisation of our own DNA in the nucleus prevents autoimmunity. We recently established that our own DNA can activate this pathway after DNA damage, when cGAS detects micronuclei. This has implications for how cells may detect early cancer-inducing events, and for how DNA damage could lead to inflammation (Mackenzie et al, Nature 2017). This PhD aims to build on these findings, addressing whether this pathway opposes cancer formation in vivo, if there are other processes that deliver DNA to the cytoplasm, and why cGAS is not activated during normal mitosis.

For further information on how to apply for this project, please visit: https://www.ed.ac.uk/mrc-human-genetics-unit/graduate-research-and-training/mrc-four-year-phd-programme-human-genetics-genomic

Funding Notes

For full funding (fees and stipend) students must be UK or EU citizens who have been resident in the UK for 3 years prior to commencement.

However, EU students with quantitative or multidisciplinary skills are eligible for full funding.

Where will I study?

University of Edinburgh

One of the world''s top universities, consistently ranked in the world top 50 and placed 20th in the QS World University Rankings 2020. We provide a stimulating working, learning and teaching environment with access to excellent facilities and attract the world''s best, from Nobel Prize winning laureates to future explorers, pioneers and inventors.

Combatting the enemy within: intracellular immune detection of genome instability to prevent cancer

University of Edinburgh College of Medicine and Veterinary Medicine

This project is no longer listed on FindAPhD.com and may not be available.

About the Project

Funding Notes

Where will I study?

University of Edinburgh

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