About the Project
Physics driven drug delivery: We intend to assess, develop, and optimise ablative fractional resurfacing (AFR) of skin, in order to achieve drug delivery of our target therapeutics. AFR is a novel laser procedure that has recently received favourable reviews for its efficacy and safety in aesthetic contexts. The procedure itself essentially consists of a series of energetic laser shots each undertaken with a tight spot focus, creating microscopic vertical ablated channels in the skin that are surrounded by a thin layer of coagulated tissue. Ablation of the SC in this controllable fashion has led to its exploitation for molecular delivery of topical drugs within the past few years, thereby de-risking this present study. Thermal collateral damage is controlled chiefly by limiting laser pulse widths, however, we will monitor and optimise this process in real time using thermal imaging, whilst developing a Franz diffusion cell to track molecular transport across the compromised skin. The tissues will also be subjected to low amplitude pulsed ultrasound in order to force dispersal of the molecular therapeutics towards the sub-dermal target plane. A critical aspect to the study will thus be to optimise the laser parameters to control the extent of coagulation, limit thermal collateral damage, and ensure the tissue plane is left in a state that predisposes it to significant update of therapeutic molecules. Ascertaining the optimized downstream ultrasound field parameters that best disperse siRNA is a second critical objective. This will provide a firm platform for a practical clinical translation
For informal enquiries about the project, contact Dr Paul Campbell (firstname.lastname@example.org)
For general enquiries about the University of Dundee, contact email@example.com
Applicants must have obtained, or expect to obtain, a first or 2.1 UK honours degree, or equivalent for degrees obtained outside the UK in a relevant discipline.
English language requirement: IELTS (Academic) score must be at least 6.5 (with not less than 5.5 in each of the four components). Other, equivalent qualifications will be accepted. Full details of the University’s English language requirements are available online: http://www.dundee.ac.uk/guides/english-language-requirements.
Step 1: Email Dr Paul Campbell (firstname.lastname@example.org) to (1) send a copy of your CV and (2) discuss your potential application and any practicalities (e.g. suitable start date).
Step 2: After discussion with Dr Campbell, formal applications can be made via UCAS Postgraduate:
Apply for the Doctor of Philosophy (PhD) degree in Physics: https://digital.ucas.com/coursedisplay/courses/07a14f7d-0d23-c83c-bae0-4dc4e2f7045f. Select the start date and study mode (full-time/part-time) agreed with the lead supervisor.
In the ‘provider questions’ section of the application form:
- Write the project title and ‘FindAPhD.com’ in the ‘if your application is in response to an advertisement’ box;
- Write the lead supervisor’s name and give brief details of your previous contact with them in the ‘previous contact with the University of Dundee’ box.
In the ‘personal statement’ section of the application form, outline your suitability for the project selected.
Interviews will be held as part of the recruitment process.
V Hegde, RP Hickerson, S Nainamalai, PA Campbell, FJC Smith, WHI McLean & DML Pedrioli
Journal of Controlled Release 196, 355-362 (2014)
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