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Comparative studies of wound and cancer inflammation in plants and animals


School of Biochemistry

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Prof P B Martin Applications accepted all year round Self-Funded PhD Students Only

About the Project

All organisms need to be able to repair wounds. A key aspect of this is combating the potential for infection when barrier layers are breached by tissue damage. Our lab is particularly interested in the wound inflammatory response and how it impacts on wound healing in both good (eg killing off infections and promoting wound angiogenesis), and bad (eg promoting scarring) ways. We are also very interested in parallels between the inflammatory responses to wounding and to cancer development. We have potential PhD projects utilising a range of model organisms (from mouse through zebrafish to Drosophila) in which we aim to compare - at transcriptomic and proteomic levels - the wound and cancer inflammatory responses and their consequences. We also would like to compare tissue repair in animals versus plants where there are no motile cells and so no standard inflammatory response, and yet they still must repair and protect themselves from infection. We hope that both overlaps and differences in these various responses will provide clues for potential therapeutic application.

For further information see: http://www.embryowound.info

References

Antonio, N., Bonnelykke-Behrndtz, M.L., Ward, L., Collin, J., Christensen, I.J., Steiniche, T., Schmidt, H., Feng, Y. and Martin, P. (2015). The wound inflammatory response exacerbates growth of pre-neoplastic cells and progression to cancer. EMBO J. 34, 2219-2236.

Gurevich D., Severn, C., Twomey, C., Greenhough, A., Cash J., Toye, A., Mellor, H. and Martin, P. (2018). Live imaging of wound angiogenesis reveals macrophage orchestrated vessel sprouting and regression. EMBO J. 37, e97786.


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