Complexes Maintaining Chromatin Structure at Masaryk University on FindAPhD.com

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Prof Jan Palecek No more applications being accepted Funded PhD Project (Students Worldwide)

About the Project

The SMC (Structure Maintenance of Chromosome) complexes are the key components of higher-order chromatin fibers and play important roles in genome stability. Three SMC complexes are present in most eukaryotic cells: cohesin (SMC1/3), condensin (SMC2/4) and SMC5/6 complex. Cohesin can make internal loops or embrace two sister chromatids (feature essential for proper chromosome segregation); condensin interconnects loops to condense chromatin during mitosis. The SMC5/6 complex is involved in the homologous recombination-based DNA repair, in replication fork stability and processing, and in cohesin regulation. However, there is not much information about its looping activity and molecular insights into these functions. In our lab, we study assembly and functions of the SMC5/6 complexes (http://www.ncbr.muni.cz/SPEC/). New student will use combination of genetic (fission yeast model), biochemical, proteomic and bioinformatic approaches to see how the enigmatic SMC5/6 complexes work.

PLEASE NOTE: before initiating the formal application process to doctoral studies, all interested candidates are required to contact Jan Paleček ([Email Address Removed]) for an informal discussion.

Information about the laboratory at: https://www.ceitec.cz/molekularni-komplexy-chromatinu-jiri-fajkus/rg51.

More information about CEITEC PhD School are available at http://ls-phd.ceitec.cz/.

References

1. Palecek, J.J. and Gruber S.: Kite Proteins: a Superfamily of SMC/Kleisin Partners Conserved Across Bacteria, Archaea, and Eukaryotes, Structure 23(12): 2183-90, doi: 10.1016/j.str.2015.10.004, 2015
2. Zabrady et al: Chromatin association of the SMC5/6 complex is dependent on binding of its NSE3 subunit to DNA. Nucleic Acids Research, 44(3), 1064-79, doi:10.1093/nar/gkv1021, 2016
3. Palecek, J.J. : SMC5/6: Multifunctional Player in Replication, Genes, 10(1): 14, pii: E7. doi: 10.3390/genes10010007, 2019
4. Adamus et al,: Molecular insights into the architecture of the human SMC5/6 complex. Journal of Molecular Biology, 432 (13): 3820-3837, doi: 10.1016/j.jmb.2020.04.024, 2020

Complexes Maintaining Chromatin Structure

Masaryk University CEITEC

This project is no longer listed on FindAPhD.com and may not be available.

About the Project

References

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