University of Leeds Featured PhD Programmes
Peter MacCallum Cancer Centre Featured PhD Programmes

Conflict and Cooperation in Prokaryote Pangenomes


School of Life Sciences

About the Project

Prokaryotes mediate most of the biogeochemical cycles on the planet, are responsible for large numbers of diseases and are used in pharmaceutical and biotechnology industries to make new and interesting compounds. One of the biggest surprises of the last 20 years has been the observation that while a typical prokaryote has a genome of a particular size, the species as a whole usually has many, many more genes. We say that prokaryote species have “pangenomes” – a collection of genes that are “core” to all members of the species and a set of genes that are present in only some of the members of the species. Why prokaryotes have pangenomes is a subject of debate (1). In this project we will develop analytical methods to help us understand how pangenomes are assembled and disassembled in prokaryotes. We will analyse large datasets of prokaryote genomes in order to examine (a) the order in which particular lineages of prokaryotes acquired new genes, (b) whether incoming genes displaced pre-existing genes and (c) what forces of conflict and cooperation exist between genes in pangenomes.

References

McInerney, J.O., McNally, A and O'Connell, M.J. (2017) Why Prokaryotes have Pangenomes. Nature Microbiology 2, 17040.

Email Now

Insert previous message below for editing? 
You haven’t included a message. Providing a specific message means universities will take your enquiry more seriously and helps them provide the information you need.
Why not add a message here

The information you submit to University of Nottingham will only be used by them or their data partners to deal with your enquiry, according to their privacy notice. For more information on how we use and store your data, please read our privacy statement.

* required field

Your enquiry has been emailed successfully



Search Suggestions

Search Suggestions

Based on your current searches we recommend the following search filters.



FindAPhD. Copyright 2005-2020
All rights reserved.