Imperial College London Featured PhD Programmes
Gdansk University of Technology Featured PhD Programmes
Scuola Superiore SantAnna Featured PhD Programmes

Conflict and Cooperation in Prokaryote Pangenomes


   School of Life Sciences

   Applications accepted all year round  Self-Funded PhD Students Only

About the Project

Prokaryotes mediate most of the biogeochemical cycles on the planet, are responsible for large numbers of diseases and are used in pharmaceutical and biotechnology industries to make new and interesting compounds. One of the biggest surprises of the last 20 years has been the observation that while a typical prokaryote has a genome of a particular size, the species as a whole usually has many, many more genes. We say that prokaryote species have “pangenomes” – a collection of genes that are “core” to all members of the species and a set of genes that are present in only some of the members of the species. Why prokaryotes have pangenomes is a subject of debate (1). In this project we will develop analytical methods to help us understand how pangenomes are assembled and disassembled in prokaryotes. We will analyse large datasets of prokaryote genomes in order to examine (a) the order in which particular lineages of prokaryotes acquired new genes, (b) whether incoming genes displaced pre-existing genes and (c) what forces of conflict and cooperation exist between genes in pangenomes.

References

McInerney, J.O., McNally, A and O'Connell, M.J. (2017) Why Prokaryotes have Pangenomes. Nature Microbiology 2, 17040.

How good is research at University of Nottingham in Biological Sciences?


Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

Email Now


Search Suggestions
Search suggestions

Based on your current searches we recommend the following search filters.

PhD saved successfully
View saved PhDs