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Construction of synthetic scaffolds enabling subcellular organelle-specific release chemistry

  • Full or part time
  • Application Deadline
    Thursday, February 21, 2019
  • Competition Funded PhD Project (Students Worldwide)
    Competition Funded PhD Project (Students Worldwide)

Project Description

Chemical reactions compatible with biological systems offer unique possibility to manipulate and study biological processes under native conditions. Our group has a long term interest in these, so-called, bioorthogonal reactions. They are mainly known as efficient chemical transformations leading to formation of covalent bonds. It has been only recently when the concept was extended to something what is known as bioorthogonal cleavage reactions. The power of this type of reactions is only slowly becoming recognized. In this project, we aim to construct a new type of releasing systems, which will enable de-caging of small molecules within specific cellular compartments. We believe that such systems will offer not only a unique possibility to deliver small biologically active molecules to particular subcellular location, but in a broader sense, to shed light on the function of individual cellular organelles. This project combines organic chemistry with modern chemical biology experiments.

How to apply

To apply for a PhD study at IOCB Prague, you must hold a Master’s degree (MSc) or the equivalent of the MSc in similar field (four or five year undergraduate degree). The application can be submitted before obtaining the Master’s degree, however, the applicant should obtain the degree within five months after the application deadline.

For more information visit our website “Call for PhD applications 2019”:

You can apply online via our application form


All general enquiries should be directed to Katerina Solcova (). Scientific enquiries can be addressed to the supervisor ().

Funding Notes

Regular monthly income of students at IOCB Prague varies depending on the faculty scholarship and supervisor's financial options.


1. Jie Li & Peng R Chen, Development and application of bond cleavage reactions in bioorthogonal chemistry, Nature Chemical Biology 2016, 12, 129-137.

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