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  Consumer and environmental microbiome effects of domestic probiotic cleaning products


   Faculty of Biology, Medicine and Health

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  Prof Andrew McBain, Dr C Knight  No more applications being accepted  Funded PhD Project (Students Worldwide)

About the Project

The use of viable bacterial spores in Microbial-Based Cleaning Products (MCBP) is gaining momentum. However, whilst there is some information in the literature reporting the use of MCBP in hospitals [1-2], their use as domestic cleaners, for example in kitchens, is not understood in terms either of their effects on microbial communities occupying hard surfaces, or the potential effects on the human microbiome.

 The proposed project will develop a detailed understanding of the transfer of microbial agents to consumers using such products. This will involve developing and characterising laboratory models of the kitchen environment. It will also involve developing the capability to sample and quantitatively analyse environmental microbiome samples using cutting-edge approaches accounting for cell viability [3-4]. Understanding will be developed in terms of how such probiotics affect the network of microbial interactions [5] and will be applied to adapt the microbiome safety framework for home care products.

Entry Requirements

Applicants are expected to hold (or about to obtain) a minimum upper second class undergraduate honours degree (or equivalent) in Microbiology or a related subject area. An interest in mathematical modelling would also be beneficial.

For information on how to apply for this project, please visit the Faculty of Biology, Medicine and Health Doctoral Academy website (https://www.bmh.manchester.ac.uk/study/research/apply/). Informal enquiries may be made directly to the primary supervisor. You MUST also submit an online application form - choose PhD Microbiology.

Equality, diversity and inclusion is fundamental to the success of The University of Manchester, and is at the heart of all of our activities. The full Equality, diversity and inclusion statement can be found on the website https://www.bmh.manchester.ac.uk/study/research/apply/equality-diversity-inclusion/


Funding Notes

BBSRC iCASE Award with Unilever. Studentship funding is for a duration of four years to commence in September 2021 and covers UK tuition fees and an annual minimum stipend (£15,609 per annum 21/22). The University of Manchester aims to support the most outstanding applicants from outside the UK. We are able to offer a scholarship that will enable full studentship to be awarded to international applicants. This full studentship will only be awarded to exceptional quality candidates, due to the competitive nature of this funding.

References

[1] Caselli E, D'Accolti M, Vandini A, Lanzoni L, Camerada MT, Coccagna M, Branchini A, Antonioli 5, Balboni PG, Di Luca D1 and Mazzacane S. (2016) Impact of a Probiotic-Based Cleaning Intervention on the Microbiota Ecosystem of the Hospital Surfaces: Focus on the Resistome Remodulation. PLoS One. 2016 17: e0148857.
[2] Vandini A, Temmerman R, Frabetti A, Caselli E, Antonioli P, Balboni PG, Platano D, Branchini A and Mazzacane S. Hard surface biocontrol in hospitals using microbial-based cleaning products. PLoS One. 26: e108598.
[3] Checinska, A Urbaniak, C, Babu Malli Mohan, G, Stepanov VG. Tran Q, 3, Wood JM, Minich J McDonald D, Mayer T, Knight R, Karouia F and Fox GE, Venkateswaran K (2019) Characterization of the total and viable bacterial and fungal communities associated with the International Space Station surfaces. Microbiome 7:50.
[4] Ni J, Hatori S, Wang Y, Li YY and Kubota K. (2020) Uncovering Viable Microbiome in Anaerobic Sludge Digesters by Propidium Monoazide (PMA)-PCR. Microb Ecol. 79:925-932.
[5] de Vries, F. T. et al. (2018). Soil bacterial networks are less stable under drought than fungal networks. Nat Commun 9, 3033, doi:10.1038/s41467-018-05516-7