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Continuous Flow Synthesis of Active Pharmaceutical Ingredients Utilising Advanced 3D Printed Reactor Designs

Project Description

In recent years flow chemistry and continuous manufacturing have been the object of increasing interest in the pharmaceutical industry. They offer the potential to improve product quality, while simultaneously reducing costs, increasing flexibility of supply and enabling miniaturization of commercial production. Flow processes offer the ability to utilize novel chemistries for the synthesis of APIs not normally accessible at scale in addition to improved selectivity and productivity. This enables improvement of individual step chemistries and also opens up new synthetic routes for Active Pharmaceutical Ingredients.

The student will work under the supervision of Dr Steven Ferguson and should have an honours level B.Sc./M.Sc. in Chemistry, Chemical Engineering or equivalent. As part of a multi-disciplinary team the student will utilize new 3D-printed advanced reactor and separation technology under development at the Synthesis and Solid State Pharmaceutical Centre in University College Dublin for novel flow syntheses of drug like molecules and intermediates. The student will collaborate in the further development of new reactor designs and will have the opportunity to build upon their qualification in chemistry but also to acquire advanced chemical engineering expertise over the course of the PhD program in Chemical and Bioprocess Engineering.

The successful candidate will form part of a multidisciplinary research team working within the Ferguson Group and SSPC Pharmaceutical Research Centre, in the UCD O’Brien Science Centre, focussed on the development of novel technologies centred on the synthesis, purification and delivery of pharmaceuticals.

Funding Notes

The student will work under the supervision of Dr Steven Ferguson and should have an honours B.ENG/M.Eng in Chemical, Biochemical, Process, Bioprocess Engineering or equivalent. Applications and enquiries should be directed to Dr. Steven Ferguson at the School of Chemical and Bioprocess Engineering, University College Dublin, Ireland (). The stipend for this position will be €18,500 + full EU or non-EU fees paid for 4 years.

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