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  Control and inhibition of virus replication


   Faculty of Biological Sciences

   Applications accepted all year round  Self-Funded PhD Students Only

About the Project

The Tuplin laboratory utilises a range of cutting-edge approaches to investigate how arboviruses - specifically Chikungunya, Dengue and Zika viruses - control replication and translation of their genomes through interactions between RNA structures, host cell proteins and non-coding RNA, and the potential of such RNA elements/interactions as novel therapeutic targets.

You will be involved in a highly novel project which utilises a multidisciplinary approach and cutting-edge methodology - combining molecular virology, genomics, quantitative proteomics, structural biology, imaging, cell biology and structural-based rational drug design. Consequently, you will gain experience across wide range of molecular biology, cell culture and virological techniques.

This is just one example of the sort of project available in my research group. The precise project will be decided upon in consultation.

For further information please see my websites listed below.

https://biologicalsciences.leeds.ac.uk/molecular-and-cellular-biology/staff/148/dr-andrew-tuplin#journal_article_div

https://astbury.leeds.ac.uk/people/dr-andrew-tuplin/

Eligibility 

You should hold a first-degree, equivalent to at least a UK upper-second class honours degree, or a MSc degree in a relevant subject.

Applicants whose first language is not English must provide evidence that their English language is sufficient to meet the specific demands of their study. The Faculty of Biological Sciences minimum requirements in IELTS and TOEFL tests are:

  • British Council IELTS - score of 6.0 overall, with no element less than 5.5
  • TOEFL iBT - overall score of 87 with the listening and reading element no less than 20, writing element no less than 21 and the speaking element no less than 22.

How to apply:

To apply for this project applicants should complete an online application form and attach the following documentation to support their application. 

  • a full academic CV
  • degree certificate and transcripts of marks
  • Evidence that you meet the University's minimum English language requirements (if applicable).
  • Evidence of funding

To help us identify that you are applying for this project please ensure you provide the following information on your application form;

  • Select PhD in Biological Sciences as your programme of study
  • Give the full project title and name the supervisors listed in this advert
Biological Sciences (4)

Funding Notes

This project is open to applicants who have the funding to support their own studies or who have a sponsor who will cover these costs.

References

Kendall C, Khalid H, Müller M, Banda DH, Kohl A, Merits A, Stonehouse NJ and Tuplin A. 2019. Structural and phenotypic analysis of Chikungunya virus RNA replication elements. Nucleic Acids Research. 47, pp. 9296-9312
Müller M, Slivinski N, Todd EJAA, Khalid H, Li R, Karwatka M, Merits A, Mankouri J and Tuplin A. 2019. Chikungunya virus requires cellular chloride channels for efficient genome replication. PLoS Neglected Tropical Diseases.
Gao Y, Goonawardane N, Ward J, Tuplin A, Harris M. 2019. Multiple roles of the non-structural protein 3 (nsP3) alphavirus unique domain (AUD) during Chikungunya virus genome replication and transcription. PLoS Pathogens.

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