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Control and inhibition of virus replication


Faculty of Biological Sciences

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Dr A.K Tuplin Applications accepted all year round Self-Funded PhD Students Only

About the Project


The Tuplin laboratory utilises a range of cutting-edge approaches to investigate how arboviruses - specificaly Chikungunya, Dengue and Zika viruses - control replication and translation of their genomes through interactions between RNA structures, host cell proteins and non-coding RNA, and the potential of such RNA elements/interactions as novel therapeutic targets.



You will be involved in a highly novel project which utilises a multidisiplinary approach and cutting-edge methodology - combining molecular virology, genomics, quantitative proteomics, structural biology, imaging, cell biology and structural-based rational drug design. Consequently, you will gain experience across wide range of molecular biology, cell culture and virological techniques.

This is just one example of the sort of project available in my research group. The precise project will be decided upon in consultation.

For further information please see my web sites.

https://biologicalsciences.leeds.ac.uk/molecular-and-cellular-biology/staff/148/dr-andrew-tuplin#journal_article_div

http://www.astbury.leeds.ac.uk/people/staff/staffpage.php?StaffID=AKT

Funding Notes

I actively encourage and support applications from International self-funded or scholarship/fellowship PhD or MSc students. International students must have a good command of both written and spoken English. Applications can be made throughout the year.

References

Kendall C, Khalid H, Müller M, Banda DH, Kohl A, Merits A, Stonehouse NJ and Tuplin A. 2019. Structural and phenotypic analysis of Chikungunya virus RNA replication elements. Nucleic Acids Research. 47, pp. 9296-9312

Müller M, Slivinski N, Todd EJAA, Khalid H, Li R, Karwatka M, Merits A, Mankouri J and Tuplin A. 2019. Chikungunya virus requires cellular chloride channels for efficient genome replication. PLoS Neglected Tropical Diseases.

Gao Y, Goonawardane N, Ward J, Tuplin A, Harris M. 2019. Multiple roles of the non-structural protein 3 (nsP3) alphavirus unique domain (AUD) during Chikungunya virus genome replication and transcription. PLoS Pathogens.
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