About the Project
Training/techniques to be provided:
Intracellular signalling measured using a) FRET-based cell imaging and b) Epifluorescence microscopy
Cell culture, transfection, gene knockdown and cell assay.
Molecular techniques including Immunoblotting, Immunofluorescence, RT-PCR and mutagenesis
Use of receptor allosteric modulators and consideration of GPCR signal and tissue bias.
Candidates are expected to hold (or be about to obtain) a minimum upper second class honours degree (or equivalent) in a related area / subject.
For international students we also offer a unique 4 year PhD programme that gives you the opportunity to undertake an accredited Teaching Certificate whilst carrying out an independent research project across a range of biological, medical and health sciences. For more information please visit http://www.internationalphd.manchester.ac.uk
As an equal opportunities institution we welcome applicants from all sections of the community regardless of gender, ethnicity, disability, sexual orientation and transgender status. All appointments are made on merit.
 Binmahfouz LS, Centeno PP, Conigrave AD, Ward DT. (2019) Identification of Serine-875 as an Inhibitory Phosphorylation Site in the Calcium-Sensing Receptor. Molecular Pharmacology. Jun 12. doi: 10.1124/mol.119.116178
 Conigrave AD, Ward DT (2013) Calcium-sensing receptor (CaSR): Pharmacological properties and signaling pathways. Best Practice & Research Clinical Endocrinology & Metabolism 27, 315-331.
 Roberts MS, Gafni RI, Brillante B, Guthrie LC, Streit J, Gash D, Gelb J, Krusinska E, Brennan SC, Schepelmann M, Riccardi D, Bin Khayat ME, Ward DT, Nemeth EF, Rosskamp R, Collins MT (2019) Treatment of Autosomal Dominant Hypocalcemia Type 1 With the Calcilytic NPSP795 (SHP635). Journal of Bone & Mineral Research May 7. doi: 10.1002/jbmr.3747
 Yarova PL, Stewart A, Sathish V, Britt Jr RD, Thompson MA, Lowe APP, Freeman M, Aravamudan B, Kita H, Brennan SC, Schepelmann M, Davies T, Yung S, Cholisoh Z, Kidd EJ, Ford WR, Broadley KJ, Rietdorf K, Chang W, Bin Khayat ME, Ward DT, Corrigan CJ, Ward JPT, Kemp PJ, Pabelick CM, Prakash YS, Riccardi D (2015) Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma. Science Translational Medicine 7(284):284ra60
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