This is a 4 year BBSRC studentship under the Newcastle-Liverpool-Durham DTP. The successful applicant will receive research costs, tuition fees and stipend (£15,009 for 2019-20). The PhD will start in October 2020. Applicants should have, or be expecting to receive, a 2.1 Hons degree (or equivalent) in a relevant subject. EU candidates must have been resident in the UK for 3 years in order to receive full support. Please note, there are 2 stages to the application process.
Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes – Implications for prediction of drug-induced liver injury, 2019, Arch Toxicol. 93: 385-399.
Real-time in vivo imaging reveals localised Nrf2 stress responses associated with direct and metabolism-dependent drug toxicity, 2017, Sci Rep, 7: 16084.
A RelA(p65) Thr505 phospho-site mutation reveals an important mechanism regulating NF-κB-dependent liver regeneration and cancer, 2016, Oncogene, 35: 4623-4632.
The NF-κB subunit c-Rel regulates Bach2 tumour suppressor expression in B-cell lymphoma, 2016, Oncogene, 35: 3476-3484.
Hypoxia induces rapid changes to histone methylation and reprograms chromatin, 2019, Science, 363: 1222-1226.
Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition, 2016, Nature Commun, 7: 13312.
Multi-scale, whole-system models of liver metabolic adaptation to fat and sugar in non-alcoholic fatty liver disease, 2018, NPJ Syst Biol Appl, 4: 33.
QSSPN: Dynamic simulation of molecular interaction networks describing gene regulation, signalling and whole-cell metabolism in human cells, 2013, Bioinformatics, 29: 3181-90.