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Correlating structure, function and components in diabetic vasculature


Project Description

Diabetes is a major global health issue, and for the UK alone complications cost an estimated £7.7bn cost to the NHS. Much of this is directly due to altered vascular physiology causing complications such as heart disease, stroke, chronic pain, retinopathy and nephropathy. To address the pathological the functional (physiological) relationship to the vascular structure must be fully considered in context to biochemical changes.
This project is to combine world leading vascular physiology techniques with new unique-to-UK nano-analysis equipment. Specifically, we will test our hypotheses on how in diabetes the biochemical fixed charge component of the vascular wall alters the function related structures.
The vascular wall as numerous layers that effect its permeability including the mechanistically linked endothelial junctions and specialised glycocalyx. Here we will take tissues assessed optically for in-vivo permeability function, correlate them with both cryo-Electron Microscopy (structure) and Cryo-OrbiSIMS (spatial component analysis). The project is based in the biomolecular laboratories of the new Centre for Biological Sciences building on University Park (main) campus, the Nanoscale and Microscale Research Centre and has a secondment in the Research Complex at Harwell for super-resolution correlative light electron microscopy.
Excellent opportunities to travel to collaborators in London, Bristol and Copenhagen.

Funding Notes

MRC IMPACT DTP studentship which offers a stipend and fee waiver for 3.5 years, plus travel and laptop allowance for UK applicants.
Application details at IMPACT DTP website: View Website
Fully funded studentships are available for UK applicants. EU applicants who are able to confirm that they have been resident in the UK for at least three years before October 2019 may also be eligible for a full award. EU students who are not able to prove that they meet the residency criteria may apply for a fees only award.

How good is research at University of Nottingham in Public Health, Health Services and Primary Care?

FTE Category A staff submitted: 33.02

Research output data provided by the Research Excellence Framework (REF)

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