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Corticothalamic interactions in perceptual salience

Institute of Physiology and Pathophysiology

Applications accepted all year round Funded PhD Project (Students Worldwide)
Heidelberg Germany Applied Mathematics Biomedical Engineering Data Analysis Medical Physics Neuroscience Medicine Psychology

About the Project

Medical Biophysics at the Institute of Physiology and Pathophysiology, Heidelberg University

Ph.D. position: Corticothalamic interactions in perceptual salience

We are seeking a highly motivated and technically oriented Ph.D. student to study neuronal circuit mechanisms underlying sensory learning and salience encoding in the thalamocortical system. The project combines behavior (texture discrimination in freely moving mice), optogenetics/chemogenetics and electrophysiology.

Key words for methods that will be used:

electrophysiology, optogenetics, in vivo, behavior, mathematical/computational modeling, cognition, learning

Desired profile:

A Diploma/Masters in a biomedical, life-science or related discipline (e.g. neuroscience, biology, medicine, physics, cognitive science). Experimental experiences in neurosciences are a prerequisite (preferably neurophysiology and / or behavior). Experience in data analysis or programming using MATLAB/Python/R etc. is strongly preferred. Experience in methods to obtain and interpret neurophysiological data, and /or behavioral assays is highly desirable. Applicants with strong analytical skills and a flair for handling large datasets are particularly encouraged to apply. The working language in the lab is English.

The application in a single pdf should include: A cover letter with a brief personal research statement, specific research interests and career goals (max 1-2 pages), two letters of recommendation, CV, academic transcripts

The desired start for the Ph.D. project is within the first quarter of 2021.

Alexander Groh

Direct application link through HBIGS PhD program

Funding Notes



References:• Multiplexed spike coding and adaptation in the thalamus. R.A. Mease, T. Kuner, A.L. Fairhall, and A. Groh. Cell Reports. (2017).

• Corticothalamic spike transfer via the L5B-POm pathway in vivo. R.A. Mease, A. Sumser, B. Sakmann and A. Groh. Cerebral Cortex. (2016).

• Cortical control of adaptation and sensory relay mode in the thalamus. R.A. Mease, P. Krieger and A. Groh. Proceedings of the National Academy of Sciences USA. (2014).

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