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Creating a new protein recognition technology


Project Description

The project is at the interface of directed evolution, structural biology and biotechnology. The goal of the work is to create a new type or protein binding technology that may become a central component in many fields of molecular recognition. By bringing together the most advanced methods of efficient directed evolution and fast structure determination, a sequence-specific recognition system is being developed as a modular technology.

Students with excellent track record and high motivation are encouraged to apply for this PhD project. Expertise in molecular biology, protein purification and characterization of proteins is a prerequisite, as well as interest in the latest methods in directed evolution. A solid understanding of structural biology is an asset.

The Plueckthun lab has a long track record for the successful design, characterization, and selection of artificial binding proteins, both for fundamental and applied research. The project will be carried out within excellent research facilities with state-of-the art equipment, and in a highly motivated, competent team.

Funding Notes

The student will be funded for the full duration of the PhD project (4-5 years) at the level set by the Swiss National Science Foundation (SNF). When joining, the student must have completed his Master's degree with good grades. The position is available immediately, but there is no particular deadline.

The student can have any nationality but should have mainly studied at a European University.

References

For more information about current research see:
http://www.bioc.uzh.ch/plueckthun

For a complete list of publications, all available as PDFs grouped by topic or year, see:
https://www.bioc.uzh.ch/plueckthun/index.php?pid=3-0-0

Recent key publications on the project:
https://www.bioc.uzh.ch/plueckthun/pdf/APpub0391.pdf
https://www.bioc.uzh.ch/plueckthun/pdf/APpub0415.pdf
https://www.bioc.uzh.ch/plueckthun/pdf/APpub0398.pdf

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