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  Creating a systems level model of the neural mechanisms underlying impaired impulse control in Parkinson's disease


   School of Sport, Exercise and Rehabilitation Sciences

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  Dr H MacDonald, Dr John-Stuart Brittain, Dr Craig McAllister  No more applications being accepted  Funded PhD Project (UK Students Only)

About the Project

Project Description

The ability to control our urges and impulses is an essential social skill, but is impaired in a diverse range of neurological disorders, including Parkinson’s disease (PD). People with PD can show a high incidence of impulse control disorders which manifest as addictive and destructive behaviours. Identifying risk factors that predict these impulse control disorders requires a better understanding of the complex neural mechanisms underlying impaired motor impulse control behaviour in PD. Our project will contribute to this understanding by utilising a multi-modal approach to examine measures of impulsivity at the level of the muscle, motor cortex and prefrontal brain areas.

The work will involve a combination of behavioural, electromyography, non-invasive brain stimulation (transcranial magnetic stimulation), electroencephalography and computational modelling techniques to investigate impulse control mechanisms in people with PD and healthy age-matched controls. This project therefore has an emphasis on interdisciplinary skills due to the combination of clinical neuroscience, cognitive psychology and motor control. Quantitative skills are a particularly prominent aspect of the research, with a focus on TMS and EEG analysis techniques. The student will gain training in advanced statistical analyses and computational modelling to quantify relationships between the diverse range of data that they will collect and analyse, so experience of or a willingness to learn Matlab is required. 

Person Specifications

Applicants should have a strong background in neuroscience/cognitive psychology, and ideally a background in non-invasive brain stimulation and experience with clinical populations or working in a rehabilitation setting.  They should have a commitment to research in neuroscience/clinical neuroscience and currently hold at least an Upper Second Class Honours Degree in neuroscience/psychology, with a MSc in a relevant area being preferable.

Applications must be resident in the UK.

Deadline for applications: 22 November 2021

Interviews: December 2021

Anticipated start date: February 2022

Biological Sciences (4) Psychology (31)

Funding Notes

Funded by the Humane Research Trust

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