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  Crystallization in Drug Delivering Liposomes


   Strathclyde Institute of Pharmacy & Biomedical Sciences

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  Prof J ter Horst, Prof Y Perrie  No more applications being accepted  Funded PhD Project (UK Students Only)

About the Project

Are you someone with a passion for science and working across scientific interfaces? Are you ambitious, self-motivated with the skills to develop new ideas and use nanotechnology to generate big ideas? Are you a UK student who has at least an Upper Second Class Honours degree in a chemical science or a related subject and looking for an opportunity to travel and work across academic and industrial sectors? Then this PhD is an ideal opportunity for you.

We are looking for applicants to join our exciting new collaboration that will create innovative new strategies to create a well-defined set of process conditions to control crystal nucleation using liposomes and microfluidics based manufacturing technologies. This project is a novel cross-disciplinary collaboration involving Prof Joop ter Horst who leads an application driven fundamental research group on industrial crystallization that facilitates the paradigm shift to continuous manufacturing in the pharmaceutical industry and Prof Yvonne Perrie, an expert in drug delivery and liposome manufacture and technology and Precision NanoSystems Inc a world leader in enabling Precision Medicine by providing a complete, cost-effective and accessible solution for the discovery and development of molecularly tailored and targeted medicines.

By joining this collaboration, you will gain from a world-class research programme in the fields of continuous manufacturing, drug delivery and microfluidics. As a PhD student you will join the Strathclyde Institute of Pharmacy and Biomedical Sciences, a leading centre for research and training focused on the discovery, development and delivery of better medicines. This project further aligns with current and future activities of the CMAC Future Manufacturing Research Hub (CMAC – www.cmac.ac.uk). CMAC delivers the fundamental and engineering knowledge on continuous pharmaceutical manufacturing processes to enable industry’s adoption of continuous manufacturing. CMAC’s state-of-the-art labs are located in the Technology & Innovation Centre of the University of Strathclyde. The student will experience an intense research environment as their project is aligned to CMAC. The student will be a member of the CMAC Doctoral Training Centre and will undertake Strathclyde’s Postgraduate Certificate in Researcher Professional Development. The student can access a large suite of high-quality research equipment within CMAC and the microfluidic group of the EEE department, present their work at national and international conferences and take part in local research days such as the CMAC open days.

Our campus is based right in the very heart of Glasgow. National Geographic named Glasgow as one of its ’Best of the World’ destinations, while Rough Guide readers have voted Glasgow the world’s friendliest city.

We look forward to hearing from interested candidates. Informal enquiries can be made to Professor Joop ter Horst ([Email Address Removed]) or Professor Yvonne Perrie ([Email Address Removed]).


Funding Notes

This is a University of Strathclyde Research Excellence Award Funded Project

Informal enquiries can be made to Professor Joop ter Horst ([Email Address Removed]) or Professor Yvonne Perrie ([Email Address Removed]).

References

1. Webb C, Forbes N, Roces CB, Anderluzzi G, Lou G, Abraham S, Ingalls L, Marshall K, Leaver TJ, Watts JA, Aylott JW, Perrie Y. Using microfluidics for scalable manufacturing of nanomedicines from bench to GMP: A case study using protein-loaded liposomes. Int J Pharm. 2020 May 30;582:119266. doi: 10.1016/j.ijpharm.2020.119266.
2. Webb C, Khadke S, Schmidt ST, Roces CB, Forbes N, Berrie G, Perrie Y. The Impact of Solvent Selection: Strategies to Guide the Manufacturing of Liposomes Using Microfluidics. Pharmaceutics. 2019 Dec 4;11(12).
3. Lou G, Anderluzzi G, Woods S, Roberts CW, Perrie Y. A novel microfluidic-based approach to formulate size-tuneable large unilamellar cationic liposomes: Formulation, cellular uptake and biodistribution investigations. Eur J Pharm Biopharm. 2019 Oct;143:51-60. doi: 10.1016/j.ejpb.2019.08.013.
4. S.A. Kulkarni, C.C. Weber, A.S. Myerson, J.H. ter Horst, Self-association during heterogeneous nucleation onto well-defined templates, Langmuir, 30(41) (2014) 12368-12375, DOI: 10.1021/la5024828.
5. R.J. Davey, S.L.M. Schroeder, J.H. ter Horst, Nucleation of Organic Crystals – A Molecular Perspective, Angewandte Chemie International Edition 52 (2013) 2166-2179, DOI: 10.1002/anie.201204824.

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