Brain tumours are the biggest cancer killer of children and adults under 40. Brain tumours reduce life expectancy by an average of 20 years, the highest of any cancer. Survival rates have improved little in over 40 years. The most common and aggressive primary brain tumour is glioblastoma (GBM). Despite intense effort to combat GBM with surgery, radiation and chemotherapy, 90-95% of patients succumb to the disease within 5 years of diagnosis and nearly all patients experience disease recurrence, usually within 6-8 months of treatment onset. It is now essential that new, better, more-targeted treatments are properly assessed in robust brain tumour models. This research proposal, built on a solid foundation of published work [1-4], aims to assess the clinical applicability of cyclin-dependent kinase inhibitors (CKIs) as a novel treatment option for GBM patients. By combining, 3D cultures, cancer stem cell populations, large scale high-content screening, light-sheet fluorescence microscopy, transcriptomic profiling and in vivo studies using PDX models, this integrative translational project, will comprehensively examine the therapeutic potential of CDK inhibitors as a treatment strategy for GBM patients.
Entry Requirements:
Minimum Upper Second Class (2.1) honours degree (or equivalent) in in biochemistry, molecular biology, biotechnology or similar
Masters and/or diploma or other higher degree qualifications
Wet lab techniques including
• Cell culture
• Western blotting
• Microscopy
• Experience in establishing new assays/techniques in the lab
How Do I Apply
To apply, please access the following link and complete the application form in full:
https://forms.office.com/Pages/ResponsePage.aspx?id=50FwYBKocEa9MDD52yEPBj6BgpLzl-ZNggs5DLWflaNUNjVSU05NQzRNU1ZJRE1PSzlNTUFLMkY5OC4u
-Unfortunately, we are unable to provide individual feedback to applicants.
-Shortlisted candidates will be invited for interview.
-At this stage only successful candidates will be contacted to submit, CV, transcripts and other relevant documentation.
- Only their referees will also be contacted at this stage for a reference.
Applications must include:
(i) a completed application form
(ii) English language requirements – see https://www.rcsi.com/dublin/postgraduate/policies-and-guidelines/english-language-requirements.
Deadline: All applications must be made online by 12 November 2021 (GMT)
It is the candidate’s responsibility to ensure the application form is completed in full on time. Late and/or incomplete applications will not normally be assessed.
Further information on the Royal College of Surgeons in Ireland can be found here: https://www.rcsi.com/