About the Project
My laboratory is focussed on understanding how cytoskeletal regulators control the formation of blood vessels – a fundamental process in biology. By using a combination of gene screening and advanced proteomics, we have managed to identify a host of novel signalling proteins involved in cytoskeletal regulation of this process. This project seeks to understand the mechanisms of blood vessel formation, and to identify novel drug targets for its clinical manipulation.
The studentship will involve training in the key techniques of cytoskeletal research, including cell migration assays, proteomics and advanced cell imaging. The project will make heavy use of the Wolfson Bioimaging Facility – one of the leading centres for microscopy in the UK. Outcomes of the project will have direct relevance for the clinical manipulation of angiogenesis; however, the study will also have broader relevance for cytoskeletal regulation in other systems.
The student will join a dynamic, international research group situated in the School of Biochemistry. Bristol is a centre for cytoskeletal research, and the student will benefit from exposure to a wide range of exciting work in this area. The city is exciting, cosmopolitan and culturally diverse, with good flight connections to European cities.
If you are a UK student, you can access this project by applying to the University of Bristol Welcome Trust Dynamic Cell PhD program, or the University of Bristol BHF PhD program in Integrative Cardiovascular Science.
Richards M, Hetheridge C and Mellor H (2015) The formin FMNL3 controls early apical specification in endothelial cells by regulating the polarized trafficking of podocalyxin. Current Biology 27, 2325-2331.
Hetheridge C, Scott AN, Swain RK, Copeland JW, Higgs HH, Bicknell R and Mellor H. (2012) The novel formin FMNL3 is a cytoskeletal regulator of angiogenesis. J Cell Sci. 125, 1420-1428.
Potente M, Gerhardt H, Carmeliet P. (2011) Basic and therapeutic aspects of angiogenesis. Cell 16, 873-87.
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