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Cytoskeleton self-organisation and microtubule-based transport

  • Full or part time
  • Application Deadline
    Wednesday, January 15, 2020
  • Competition Funded PhD Project (Students Worldwide)
    Competition Funded PhD Project (Students Worldwide)

Project Description

Disciplines: Physical Sciences, Biological and Medical Sciences,
Subjects: Biophysics, Biochemistry, Cell Biology / Development
Type: PhD Research Project

Project Description:

In this project, you will study the dynamic self-organisation of microtubules into paraxial arrays either in differentiating skeletal myoblasts or in neurons. You will either use gene editing to fluorescently label endogenous cytoskeletal proteins and perform live cell imaging experiments using lattice light sheet imaging and expansion microscopy to quantitatively assess changes in the microtubule array organisation upon specific perturbation of microtubule crosslinkers. Alternatively, you will apply imaging-based biochemical assays to reconstitute microtubule organisation or microtubule-based transport from purified proteins in vitro. Please see recent publications from our lab describing these assays (Mogessie et al eLife 2015: https://elifesciences.org/articles/05697 ; Siddiqui et al Nature Comms 2019: https://www.nature.com/articles/s41467-019-10644-9).

You will be supervised by Dr Anne Straube in the Centre for Mechanochemical Cell Biology at the University of Warwick. You will become part of an international and interdisciplinary environment that is well resourced with access to state-of-the-art equipment as well as a vibrant community with internal and external seminar series. For more information see: http://mechanochemistry.org/Straube/

You will expected to compete for scholarship funding. Thus you should hold or expect to achieve an excellent university degree (BSc, MSc or equivalent) in a relevant field, already have some research experience, prizes and/or publications. Applications for October 2020 entry will require application by mid January.

Please send an expression of interest including a statement of career intentions, a full CV (including list of publications), degree certificates or transcripts plus two academic references to Dr Straube ().

Funding Notes

You will expected to compete for scholarship funding. Thus you should hold or expect to achieve an excellent university degree (BSc, MSc or equivalent) in a relevant field, already have some research experience, prizes and/or publications. Applications for October 2020 entry will require application by mid January to be considered for WMS scholarship, Warwick Chancellor's International Scholarship or Warwick EU Scholarships. Interested high-calibre students will also be supported to apply for other scholarships and doctoral training programmes they might be eligible for.

References

Siddiqui, N.*, Zwetsloot, A.J.*, Bachmann, A., Roth, D., Hussain, H., Brandt, J., Kaverina, I. and Straube, A. (2019)
PTPN21 and Hook3 relieve KIF1C autoinhibition and activate intracellular transport
Nature Communications (10: 2693, doi: 10.1038/s41467-019-10644-9

Roth, D., Fitton, B.P., Chmel, N., Wasiluk, N. and Straube, A. (2018)
Spatial positioning of EB family proteins at microtubule tips involves distinct nucleotide-dependent binding properties.
Journal of Cell Science, doi: 10.1242/jcs.219550.

Mogessie, B., Roth, D., Rahil, Z. and Straube, A. (2015)
A novel isoform of MAP4 organises the paraxial microtubule array required for muscle cell differentiation.
eLife, 4:e05697. doi:10.7554/eLife.05697.

Straube, A. and Merdes, A. (2007)
EB3 regulates microtubule dynamics at the cell cortex and is required for myoblast elongation and fusion.
Current Biology, 17, 1318-1325.

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