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Data-driven design of complex functional proteins

  • Full or part time
    Dr G Stracquadanio
  • Application Deadline
    Sunday, January 05, 2020
  • Competition Funded PhD Project (Students Worldwide)
    Competition Funded PhD Project (Students Worldwide)

Project Description

Second Supervisor: Chris Wells Wood, School of Biological Sciences,

Proteins are the building blocks of life as they are responsible for all the functions in a cell. Rapid advances in computational protein design now means that, given enough compute, it is relatively routine to design amino-acid sequences that fold into a desired 3D structure. As a result, it has been said that protein design has “come of age” [1]. However, in order unlock the full potential of protein design, structure alone is not enough. We must develop tools to guide the design process in order to create complex functional proteins with properties tuned to their intended application.

Here we propose to improve the reliability of the design process and target specific functions using a machine learning approach, specifically deep-generative models, such as Bayesian deep learning and variational autoencoders. We aim to create an algorithm that can generate amino-acid sequences with targeted functional properties. The design strategy will be tested at scale using state-of-the-art experimental automation, and applied to tackle real-world challenges in synthetic biology.

The ideal candidate either has a background in mathematics, computer science, bioinformatics, statistics, physics or related fields; or biochemistry/molecular biology but can demonstrate a strong mathematical background. He/she is strongly motivated to develop a competitive profile in protein engineering and machine learning and likes to work in a fast pace environment. We put a strong emphasis on reproducible research; the candidate will receive training in advanced research software engineering and in workflows for data analyses. The ideal candidate is expected to have good knowledge of either Python or C.

http://www.stracquadaniolab.org and http://www.wellswoodresearchgroup.com

Funding Notes

The “Visit Website” button on this page will take you to our Online Application checklist. Please complete each step and download the checklist which will provide a list of funding options and guide you through the application process.

If you would like us to consider you for one of our scholarships you must apply by 5 January 2020 at the latest.

References

Huang PS, Boyken SE and Baker D (2016) Nature, 537, 320-327.

How good is research at University of Edinburgh in Biological Sciences?

FTE Category A staff submitted: 109.70

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities


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