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Deciphering Clonal Somatic Alterations associated with Homologous Recombination Deficiency and Synthetic Lethality in Mesothelioma

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  • Full or part time
    Prof D Fennell
    Prof F Dudbridge
    Dr J Luo
  • Application Deadline
    No more applications being accepted
  • Competition Funded PhD Project (European/UK Students Only)
    Competition Funded PhD Project (European/UK Students Only)

Project Description

The goal of this project is to understand 1. How, when and where homologous recombination deficiency arises in mesothelioma, 2. Whether a specific mutational signature (sig3) can predict response to PARP inhibition in primary cell lines grown from patient tumours, and 3. Examine the clinical impact of HRD in mesothelioma. Based on these analyses it is expected that a new phase II clinical trial of PARP inhibition in mesothelioma will be developed, using a refined stratification protocol to enrich for patients’ mesotheliomas likely to achieve a high response rate. Imagen will be a closely involved partner not only for this project, but also the clinical development pathway.

Entry requirements:
You must hold (or be about to obtain) a First or an Upper Second Class UK undergraduate degree or an equivalent degree from a recognised EU institution, in an area relevant to the projects you are applying for.

Qualifications (or a combination of qualifications and experience) which demonstrate equivalent ability and attainment will also be considered. For example, a less than sufficient first degree may be enhanced to meet the requirements by the acquisition of a Distinction at Masters level or significant research experience gained from employment).

Informal enquiries:
If you have any questions or would like to find out more about IMPACT, please get in touch.
Email us at [Email Address Removed]

Eligibility:
UK/EU applicants only

To apply please refer to https://more.bham.ac.uk/mrc-impact/phd-opportunities/

Funding Notes

The Studentship provides 3.5 years of Stipend at UKRI rates and Tuition fees at UK/EU rates.



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