Prof Ian Eperon, Prof P Bradding, Dr Cyril Dominguez
No more applications being accepted
Competition Funded PhD Project (European/UK Students Only)
About the Project
CADM1 is a tumour suppressor silenced in many carcinomas. CADM1 over-expression is also found in adult T cell leukaemia/lymphoma, and promotes tissue invasion and survival. CADM1 exists in several isoforms through alternative splicing. SP4 is the principal functional isoform in human lung mast cells (HLMCs) and the leukemic human mast cell line HMC-1. HLMCs also express the longer SP1 isoform. We have demonstrated differences in survival and adhesion of HLMCs overexpressing either only SP4 or mixed isoforms, with SP1 playing a dominant-negative role in HLMC survival. We postulate that the high level of the SP4 isoform in malignant HMC-1 cells and lack of SP1 contributes to the malignant phenotype. In this project, we will investigate the mechanisms and regulation of CADM1 alternative splicing, with a view to driving this towards specific isoform expression, for example, switching from SP4 (pro-survival) to SP1 (pro-apoptosis) in mast cell leukaemia/mastocytosis or adult T cell leukaemia/lymphoma.
Entry requirements
https://www2.le.ac.uk/research-degrees/funding/life-sciences/LISCB_MCBadvert2019.pdf
Applicants are required to hold/or expect to obtain a UK Bachelor Degree 2:1 or better in a relevant subject. The University of Leicester English language requirements apply where applicable.
How to apply
You should submit your application using our online application system:
https://www2.le.ac.uk/research-degrees/phd/applyphd
Apply for a PhD in Molecular and Cell Biology for September 2019
In the funding section of the application please indicate you wish to be considered for a LISCB/MCB 2019 Studentship
In the Proposal section of the online application please list the names of the supervisor/projects you want to be considered for. (You do not need to submit a separate application for each project).
Project / Funding Enquiries: [Email Address Removed]
Application enquiries to [Email Address Removed]
Closing date for applications 6 January 2019
Funding Notes
3 Year studentship providing fee waiver at UK/EU rates and stipend at RCUK rates
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