*Application closing date has been extended for this project*
Single-cell chromatin (in)accessibility architecture will shed light on a central question of epigenomic regulation: how are short time variations in chromatin (in)accessibility synchronised across the epigenome? This study will enhance our understanding of the interrelationship of aberrant epigenetics, chromatin dynamics and cellular plasticity in cancer, in particular squamous cell carcinomas.
(In)accessible chromatin organization across the (epi)genome echoes a crosstalk of interactions where enhancers, promoters and chromatin-binding factors cooperatively regulate gene expression. Deviant DNA-methylation and histone-modifications are hallmarks of cancers, and inhibitors of DNA-methyltransferases, histone-deacetylases and -methyltransferases are used in cancer therapeutics. Yet little is known about the molecular basis and regulatory mechanisms underlying alterations in chromatin (in)accessibility and the activities of nucleosome remodelers and their roles in cancers.
This study will investigate the role of the Nucleosome remodeling and histone deacetylase (NuRD) complex in initiating (in)accessibility remodelling and address the elusive link between chromatin remodelers and squamous cell carcinomas, hence uncovering novel targets towards discovering innovative therapeutic approaches. We will illuminate how chromatin (in)accessibility delineates an inventory of regulatory regions within the (epi)genome and how these epigenetic features are dynamically regulated to control gene expression in a subset of squamous cell carcinomas.
Funding eligibility: ROI (and EU applicants with pre-settled/settled) status may be eligible for funding. Please review the DfE T&C’s.
ENTRY REQUIREMENTS
You must hold or expect to get an upper second class honours degree from a university in the UK or Ireland, or qualifications and experience considered by the University as equivalent to that standard. Candidates who already hold a doctoral degree, or who have registered on a PhD for one year (or part-time equivalent) or not eligible.
English Language
Candidates applying from countries where the first language is not English should produce evidence of their competence through a qualification such as IELTS or TOEFL score.
The minimum recommended score for the School of Medicine, Dentistry and Biomedical Science is:
· IELTS score of 6.0 with not less than 5.5 in each of the four component elements of listening, reading, speaking and writing taken within the last 2 years;
· TOEFL score of 80+ (internet basted test), taken within the last 2 years, with minimum component scores of; Listening 17, Reading 18, Speaking 20, Writing 17);
· A valid Certificate of Proficiency in English grade A or B;
· A valid Certificate of Advanced English grade A; or
· A first or upper second class honours degree from a university based in the UK, Republic of Ireland or other suitably quality assured location in a country deemed by the UK Border Agency to be majority English speaking.
For a list of English Language qualifications also accepted by the School and University please see the following link:
http://www.qub.ac.uk/International/International-students/Applying/English-language-requirements/#English
INTO Queen’s English Language Courses offers both pre-sessional and in-sessional courses in English for academic purposes and study skills. Courses vary in length and full information can be obtained at: https://www.qub.ac.uk/International/International-students/Applying/University-Preparation-Courses/INTOEnglishlanguagecoursesatQueens/
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