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Deconstructing the Role of the MOZ/KAT6A Double Winged Helix Domain in Gene Regulation and Disease

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  • Full or part time
    Dr D Heery
  • Application Deadline
    No more applications being accepted
  • Competition Funded PhD Project (European/UK Students Only)
    Competition Funded PhD Project (European/UK Students Only)

Project Description

A PhD project (MRC Impact funded) is available in the Gene Regulation & RNA Biology Laboratory, University of Nottingham under the supervision of Professor David M Heery. The project will involve a structure/ function characterisation of a novel domain within the gene regulatory protein KAT6A/ MOZ. Mutations in this gene are associated with childhood leukemias and neurodevelopmental syndromes. KAT6A/ MOZ has multiple functions, one of which is as an epigenetic regulator controlling histone acetylation. Our long-term aim is to understand the role of a double winged helix domain in the pathology of these conditions. The project will provide the opportunity to learn a range of molecular and cell biology techniques including protein purification/ crystallisation, DNA binding assays, site-directed mutagenesis and CRISPR CAS9 editing. The project involves a collaboration with Dr Ingrid Dreveny (Structural Biology) and Dr Ralf Flaig at Diamond Light Source, RC Harwell.

For further information and details on how to apply please contact [Email Address Removed]

Funding Notes

The studentships will commence in October 2020, and a stipend (£15,009 for 2019/20) and fee waiver for 3.5 years is available for UK applicants, plus research training support grant, travel and laptop allowance.

Fully funded studentships are available for UK applicants. EU applicants able to confirm that they have been resident in the UK for at least three years before October 2020 may also be eligible for a full award. EU students who are not able to prove that they meet the residency criteria may apply for a fees only award.

Interviews take place week commencing 17 February 2020.

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