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Defence evolution under protective symbiosis: how do nuclear and symbiont defences interact?


   Faculty of Health and Life Science

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  Prof G Hurst, Dr T Price  No more applications being accepted  Self-Funded PhD Students Only

About the Project

Animals live in symbiosis with microbes. The presence of symbionts modifies the biology of the host in fundamental ways. In insects and other arthropods, symbionts have become part of the genetic inheritance – passed from a female to her progeny in or on eggs. There heritable symbionts provide many services – one of which is acting as part of the defence machinery: protective symbiosis. The defence of an individual is therefore a property of both the defences encoded in the nuclear genome and those provided by the microbe. This project will investigate how these systems interact. We can ask this question at an individual level: do the defences systems ‘add up’ – or does possessing both forms produce more or less benefit than this? We can also view this at the population level – does evolution favour having two systems, or is it that selection retains just the most efficient system? We’ll investigate these in the Drosophila-Spiroplasma-Leptopilina wasp model system. This system benefits from lab tractability for experiments, combined with detailed genetic knowledge of resistance systems that allows us to track the precise frequency of resistance variants over time using PCR. You’ll benefit from training in evolutionary ecology, molecular ecology, experimental design and analysis. You’ll join a team of symbiosis researchers but will also work in a wider fruit fly model laboratory studying genetic and sexual conflict. You may also elect to take the work down your own enquiry routes – for instance examining if the environment determines evolutionary trajectory, or making wider predictions through mathematical modelling.

Informal enquiries and expressions of interest in applying may be made to Professor Hurst on: [Email Address Removed]

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