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Defining and measuring mid-flexion instability following total knee replacement

  • Full or part time
  • Application Deadline
    Tuesday, April 30, 2019
  • Competition Funded PhD Project (European/UK Students Only)
    Competition Funded PhD Project (European/UK Students Only)

Project Description

Total knee replacement (TKR) is an established treatment for knee osteoarthritis and leads to a satisfactory outcome in over 75% of patients. However, up to 25% of patients are not entirely satisfied with their TKR. Patient dissatisfaction has been associated with inadequate functional outcome, especially during negotiation of stairs and slopes. This phenomenon, known as mid-flexion instability, is characterised as a perception that the replaced knee is unsteady during certain tasks. It is believed to be caused by excessive anterior-posterior motion of the implant during activities of daily living, however clinical evidence of this is currently limited.

This PhD project aims to:
- Better define mid-flexion instability following TKR.
- Use clinical motion capture technology to quantify knee stability during acts of daily living which are believed to cause mid-flexion instability.
- Develop a means to better identify patients with mid-flexion instability post-TKR.

This study will provide clinicians and researchers with quantitative and valuable information on mid-flexion instability following TKR. It could also provide clinicians with a method of identifying patients with mid-flexion instability, allowing them to personalise treatment plans to improve the functional outcomes of future patients.

The project will provide an ideal basis to progress into eminent postdoctoral positions in the biological/medical sciences or engineering and regenerative medicine.

Entry Requirements
Candidates should hold a minimum upper-second undergraduate degree (or equivalent) in biomedical engineering, sports engineering, mechanical engineering, software engineering, human movement science, biology, biotechnology, prosthetics & orthotics, medical sciences or computer science. A Masters qualification in a similar area would be an advantage.

Funding Notes

This project is fully funded by Medacta Orthopaedic Research and Education (MORE) Institute with stipend at £15,009 per annum. Starting September 2019 for 3 years. If you are interested please make direct contact with the Supervisor to discuss the project . You MUST also submit an online application form - choose PhD Cell Matrix Research.

As an equal opportunities institution we welcome applicants from all sections of the community regardless of gender, ethnicity, disability, sexual orientation and transgender status. All appointments are made on merit.


König, C., Matziolis, G., Sharenkov, A (2011). “Collateral ligament length change patterns after joint line elevation may not explain midflexion instability following TKA.” Medical Engineering and Physics 33: 1303-1308.

Vince, K (2016). “Mid-flexion instability after total knee arthroplasty: Woolly thinking or a real concern?” The
Bone and Joint Journal 98B(1A): 84-88.

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