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Defining disease mechanisms and treatment responses in mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) by multi-omics profiling and bioinformatical analysis

  • Full or part time
  • Application Deadline
    Wednesday, January 01, 2020
  • Competition Funded PhD Project (European/UK Students Only)
    Competition Funded PhD Project (European/UK Students Only)

Project Description

Clinical trials require validated endpoint measures to provide an assessment of the success of the study treatment. The selection of trial endpoint measures for rare diseases presents considerable challenges due to low patient numbers, clinical heterogeneity and the absence of appropriate or validated endpoints. Biomarker profiling is an important investigative approach in unravelling biochemical pathways alterations in disease and measuring responses to treatment. This studentship will work in parallel with an international clinical trial for the treatment of mitochondrial neurogastrointestinal encephalomyopathy (MNGIE), an ultra-rare disease, with the aim of defining the disease mechanisms of MNGIE and assess the responses to trial treatment by employing biomarker profiling approaches and bioinformatics analyses.

This project will equip the student with a range of versatile skills including clinical sample processing, miRNA isolation, miRNA expression profiling, and metabolite analysis using polar and semi-polar Liquid Chromatography with tandem mass spectrometry technologies, bioinformatical and statistical analyses. In addition, the student will gain an in-depth understanding of issues relating to rare disease research, the operation of clinical trials, and knowledge of the codes of ethics and regulations that guide clinical research.

Potential applicants are strongly encouraged to contact the supervisors to discuss project details.

The current studentship is part of the MRC London Intercollegiate Doctoral Training Partnership (MRC-LID) between The London School of Hygiene and Tropical Medicine (LSHTM) and St. George’s University of London (SGUL)

Subsequently applications can be made by following the instructions on the MRC-LID site at http://mrc-lid.lshtm.ac.uk/apply/.

Please click on the following link for more information about the MRC-LID programme: http://mrc-lid.lshtm.ac.uk/

For more information on funding please go to: http://mrc-lid.lshtm.ac.uk/faqs/

The deadline for applications is Wednesday 1 January 2020.

Funding Notes

To be eligible for a full studentship award applicants must
(a) hold, or expect to obtain before September 2020, a 1st or 2.1 Honours degree (as a minimum), and
(b) be a UK or EU citizen, and
(c) have maintained ordinary residence in the UK continuously for the 3 years preceding 1 September 2020.

To be generally eligible for a fees-only studentship award applicants must
(a) hold, or expect to obtain before September 2020, a 1st or 2.1 Honours degree (as a minimum), and
(b) be a UK or EU citizen.

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