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  Defining long term outcomes in patients with Systemic Lupus Erythematosus (SLE)


   Institute of Inflammation and Ageing

   Applications accepted all year round  Self-Funded PhD Students Only

About the Project

We are seeking talented, motivated students with a passion for research in systemic autoimmunity to join the Lupus Research Group led by Dr John Reynolds (https://www.birmingham.ac.uk/staff/profiles/inflammation-ageing/reynolds-john.aspx). Applicants should have a first or upper second-class degree in a relevant scientific discipline, and who are self-funded or have typically applied for, or secured funding for their studies from their government, employer or associated charitable organisations.

RESEARCH IN SYSTEMIC LUPUS ERYTHEMATOSUS (SLE)

The Lupus Research Group is part of the wider Rheumatology Research Group within the Institute of Inflammation and Ageing at the University of Birmingham. We are interested in understanding the pathogenesis of SLE, personalised therapies for SLE and the long-term outcomes of patients with SLE.

We have three main areas of interest:

• Understanding the long-term outcomes of patients with SLE and prediction of those patients who are at risk of worse outcomes (including irreversible organ damage);

• Personalised approaches to the treatment of SLE;

• Defining the pathogenesis of SLE to identify novel treatment targets and biomarkers of treatments response/prognosis with a focus of cutaneous lupus erythematosus (CLE);

We have ongoing projects examining:

• The development of irreversible organ damage in SLE and identification of patients at the highest risk;

• Resolution of cutaneous lupus (CLE) in humans at the single-cell level;

• The role of exercise in modifying immune responses in SLE

• Patterns, and predictors, of skin flare in patients with SLE;

We analyse larger clinical datasets, including our own Birmingham Lupus Cohort, and data from clinical trials. We use traditional statistics and machine-learning models to predict outcomes of patients and identify novel risk factors. In CLE we use cutting-edge technologies to identify transcript and protein changes in the skin at the single cell level.

PhD projects, using these approaches are available to self-funded or scholarship-funded graduates interested in joining IVB.

APPLICATION ROUTES

Self-funded or scholarship-funded graduates interested in joining IVB can select one of 3 different routes for undertaking a PhD in the field of Inflammation and Ageing.

Applicants with research experience and/or Master’s degree should apply directly to the Institute of Inflammation and Ageing for either a 3 or 4 year full-time PhD – https://www.birmingham.ac.uk/postgraduate/courses/research/med/inflammation-ageing.aspx. This route requires applicants to submit a drafted research proposal.

Applicants seeking additional research experience or who have yet to complete a Master’s degree should apply to the 4 year Integrated Doctoral Training Programme in Life Sciences for Health, which combined a MRes and PhD – https://www.birmingham.ac.uk/postgraduate/pgr/idtp/index.aspx.

Applicants will need to submit the following documentation during the application process.

• Detailed CV, including your nationality and country of birth;

• Covering letter highlighting your research experience/capabilities and why you wish to undertake a PhD in the team;

• Names and addresses of two referees;

• Copies of your degree certificates with transcripts written in English;

• Evidence of your proficiency in the English language, if applicable.

• Evidence of scholarship application/funding or independent funding.

ADDITIONAL INFORMATION

University of Birmingham offers pre-sessional English Language courses through the Birmingham International Academy – https://www.birmingham.ac.uk/international/bia/presessional/index.aspx

For additional information on postgraduate studying at University of Birmingham please click - https://www.birmingham.ac.uk/study/postgraduate

For additional information on research at the College of Medical and Dental Sciences please click – https://www.birmingham.ac.uk/research/activity/mds/index.aspx

For additional information on research in the Institute of Inflammation and Ageing please click – https://www.birmingham.ac.uk/research/inflammation-ageing/index.aspx

For additional information on research within the Rheumatology Research Group please click - https://www.birmingham.ac.uk/research/inflammation-ageing/research/rheumatology-research-group/index.aspx

Medicine (26)

Funding Notes

Applicants are invited from self-funded or scholarship-funded graduates ONLY

Applicants will be self-funded or will have typically applied for, or secured funding for their studies from their government, employer or associated charitable organisations.

Overseas graduates require IELTs of 6.5 overall.

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