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Defining the mechanism of galectin-3 mediated TGFβ activation and its role in lung fibrosis

Project Description

This PhD studentship will investigate how the deadly disease, Idiopathic Pulmonary Fibrosis develops, and help design new therapies to treat it.
Idiopathic pulmonary fibrosis (IPF) is a progressively fatal lung disease in which only half the people diagnosed survive more than 3 years. IPF is characterized by increased scar deposition in the lung following excessive growth of fibroblasts which prevents the lungs functioning normally. As more scar tissue is produced, symptoms worsen until patients ultimately die of respiratory failure or its complications. Currently there is no cure for IPF.

This PhD studentship offers successful applicants the exciting opportunity to work in world-leading laboratories at the University of Nottingham investigating new treatments for this fatal disease. Galectin-3 is a protein that promotes the development of lung scarring through effects on a potent pro-scarring biochemical pathway involving TGFβ and integrins. In collaboration with Galecto Biotech, the student will evaluate strategies for targeting galectin-3 in IPF using a wide range of state-of-the-art technologies, molecular, biochemical and imaging techniques, and includes a 1-year placement studying structural molecular biology at the world-leading MRC Research Complex at Harwell, Oxfordshire. The student will also receive training in the development and utilization of animal models of disease, clinical pharmacology and translational medicine and will undertake a 3-month industrial placement with Galecto Biotech.

Funding Notes

MRC IMPACT DTP studentship which offers a stipend and fee waiver for 3.5 years, plus travel and laptop allowance for UK applicants.
Application details at IMPACT DTP website: View Website
Fully funded studentships are available for UK applicants. EU applicants who are able to confirm that they have been resident in the UK for at least three years before October 2019 may also be eligible for a full award. EU students who are not able to prove that they meet the residency criteria may apply for a fees only award. Deadline Noon Friday 1 March 2019.

How good is research at University of Nottingham in Clinical Medicine?

FTE Category A staff submitted: 103.70

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

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