About the Project
This project aims to bridge a fundamental gap in our knowledge to link epigenetic modifications, circadian timing and the control of female fertility. Using neuroanatomical examination, analysis of gene expression, epigenome sequencing, bioinformatics, physiologic interrogations, and studies of in vivo functional outcomes, the student will identify the epigenetic signals and brain substrates regulating the ovarian cycle. The data generated from this studentship will revolutionise our understanding of non-hormonal; molecular-driven control of reproduction.
The student will gain experience in a range of advanced laboratory techniques that will include sophisticated physiological and whole animal experimentation. Training will be further enhanced by participation in GRADskills, an award-winning skills development programme for researchers. The student will work primarily in Dr Tello’s laboratory, situated in the state-of-the-art Medical and Biological Sciences Building in St Andrews. Dr Tello’s research interfaces cellular biology, pharmacology, and reproductive physiology with the goal of understanding and treating fertility disorders emanating from the brain and pituitary. Dr Stevenson (IBAHCM, University of Glasgow) will be the second supervisor on this project. He will provide specialist knowledge on DNA methylation and assist the student in identifying which gene programs are influenced by changing epigenetic signals.
For further details on the project and informal enquiries please contact Dr Javier Tello on [Email Address Removed].
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