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Defining the sequence requirements for neo-centromere function in the fission yeast Schizosaccharomyces pombe


Project Description

Centromeres are the regions of the chromosome necessary for accurate segregation at cell division. They bind a complex set of proteins called the kinetochore which in turn tethers the chromosome to the microtubules of the spindle at cell division. We have recently defined the sequence requirements for native centromere function and kinetochore binding in the fission yeast Schizosaccharomyces pombe. When centromeric DNA is deleted however the kinetochore complex will bind at low frequency to other regions of the chromosome that are not related in sequence to the native centromeric DNA. This poses the question of how are conserved set of proteins can bind to two different type of DNA sequences. The student will use genetics, genomics and molecular biology to address this question.

The University of Nottingham is one of the world’s most respected research-intensive universities, ranked 8th in the UK for research power (REF 2014). Students studying in the School of Life Sciences will have the opportunity to thrive in a vibrant, multidisciplinary environment, with expert supervision from leaders in their field, state-of-the-art facilities and strong links with industry. Students are closely monitored in terms of their personal and professional progression throughout their study period and are assigned academic mentors in addition to their supervisory team. The School provides structured training as a fundamental part of postgraduate personal development and our training programme enables students to develop skills across the four domains of the Vitae Researcher Development Framework (RDF). During their studies, students will also have the opportunity to attend and present at conferences around the world. The School puts strong emphasis on the promotion of postgraduate research with a 2-day annual PhD research symposium attended by all students, plus academic staff and invited speakers.

Funding Notes

Home applicants should contact the supervisor to determine the current funding status for this project. EU applicants should visit the Graduate School webpages for information on specific EU scholarships View Website. International applicants should visit our International Research Scholarships page for information regarding fees and funding at the University View Website.

Related Subjects

How good is research at University of Nottingham in Biological Sciences?

FTE Category A staff submitted: 90.86

Research output data provided by the Research Excellence Framework (REF)

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