About the Project
The supervisors for this project are a team of academic clinicians (surgeons and oncologist) from the Colorectal and Peritoneal Oncology Centre (CPOC) research group based at Academy of Surgical Oncology, The Christie Hospital and the Manchester Cancer Research Centre, UK. CPOC is a high volume national peritoneal tumour service which treats over 50 CRPM patients/year using specialised cytroreductive surgery (CRS) techniques and hyperthermic intraperitoneal chemotherapy(HIPEC). This has allowed the generation of one of the world’s largest CRPM tissue biobanks fully licensed by the Human Tissue Authority. This project will access the biobank allowing the successful PhD candidate to undertake detailed molecular biological characterisation (genomic and transcriptomic) of up to 200 formalin-fixed paraffin-embedded (FFPE) paired CRPM samples (primary colorectal cancer and metastasis). Supported by a dedicated research associate they will be enabled to develop laboratory/bench skills exploring de-regulated pathways involved in the peritoneal signature of metachronous CRPM. Academic and clinical supervisors will support the integration of these laboratory pathways with the clinical database allowing translational application of the knowledge gained from these studies.
All applicants must:
• Hold an undergraduate degree in medicine
• Ideally be undergoing training in an appropriate clinical speciality
If you are interested, please make direct contact with the Lead Supervisor to discuss the project.
For information on how to apply for this project, please visit the Faculty of Biology, Medicine and Health Doctoral Academy website (https://www.bmh.manchester.ac.uk/study/research/apply/). Informal enquiries may be made directly to the primary supervisor. You MUST also submit an online application form - choose PhD Cancer Sciences
As an equal opportunities institution we welcome applicants from all sections of the community regardless of gender, ethnicity, disability, sexual orientation and transgender status. All appointments are made on merit.
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