Design and 3D-Printing of Biomaterials for Cardiovascular Applications

There is huge scope to replicate the complex nature of tissue, through the design and additive manufacturing (3D printing, 3DP) of biomaterials. Extrusion-based bioprinting of hydrogels, has been shown to create orthotropic, viscoelastic and hyperelastic material properties. This is of interest to the replication of many types of tissue, and in this project will be investigated with relation to arteries. Arterial tissue has a distinct 3 layered structure, of which the mechanical properties vary greatly depending on location in the cardiovascular tree and disease pathology. Replicating the mechanical properties of such tissue is of great interest, either as a base for a tissue scaffold or graft, or vessel mimicking materials used for the development of diagnostic tools and interventions.

To date, extrusion-based bioprinting of hydrogels, has been shown to create orthotropic properties relative to the toolpath [1]. Furthermore, combining the mechanical properties of hydrogels, within an upscaled in-silico model, has shown that the design of interfaces, relative to a multi-layered graft influences the intramural stress distribution [2]. This research project will utilise a sub-zero bioprinter to explore process parameters within the design of 3DP hydrogels, and the effect on the mechanical properties of the specimen. The characterised mechanical properties will be implemented into an in-silico model, to explore design parameters with respect to a multi-layered system. The project will require the applicant to be confident in laboratory skills and/or computational skills. Experience of 3D printing is a desirable skill.

Person Specification

Essential:

• A first-class degree in a relevant discipline (Engineering (Mechanical or Chemical), Material Sciences, Physics, Applied Mathematics)

• To have met the University of Birmingham English Language requirements (e.g. IELTS 6.0 with no less than 5.5 in any band) by the point of application.

Desirable:

• Good knowledge of engineering, design, mechanics and materials

• Experience in performing experimental work, collecting data and analysing research findings

• Experience in performing computational work (e.g. ABAQUS)

• Experience with CAD/CAM software

How to apply

Eligible applicants should first send an expression of interest to Dr Lauren Thomas-Seale (L.E.J.Thomas-Seale@bham.ac.uk), including the following:

• 200 words cover letter on how your experience, qualifications and research interest aligns with this position

• CV including your academic and work experience with the names of two referees.

We value diversity and inclusion at the University of Birmingham and welcome applications from all sections of the community. The Thomas-Seale group is founded on the principle of inclusivity in research, should applicants have any enquiries about how to conduct a PhD with reasonable adjustments for a protected characteristic, they are encouraged to contact the Dr Thomas-Seale.