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Design of emulgel drug delivery system of sorbitol derivatives gelators to improve the skin permeability of hydrophilic and hydrophobic drugs.

  • Full or part time
  • Application Deadline
    Applications accepted all year round
  • Competition Funded PhD Project (European/UK Students Only)
    Competition Funded PhD Project (European/UK Students Only)

About This PhD Project

Project Description

Fee Waiver Scholarships for MSc by Research

This project aims to develop an innovative emulgel-based delivery system for delivery of key hydrophobic drugs, cosmeceutical agents and herbal ingredients through dermal or topical routes of administration as well as improving the skin permeability to hydrophilic drugs. This approach has the potential to achieve therapeutic levels of key drugs through the skin or mucosal membranes via simple non-invasive methods.
The project involves chromatography and separation techniques, full drug formulation studies, drug loading efficiency, release kinetics and in vitro bioassay across a variety of hydrophilic and hydrophobic drugs in addition to in vitro toxicity testing. This will be followed by full proof of this emulgel system to enhance absorption and therapeutic efficacy (for the drug molecule the Lutein; a known anti-aging skin agent) with the project goal being to assess whether is suitable for in vivo studies on animal models and further in humans.
Main steps of the study
(1) The preparation of sorbitol derivative based gel system and o/w emulsion incorporation into this system.
(2) Full characterization of the system (Stability, SEM or TEM, DLS….etc)
(3) Understanding the uptake of 2 selected model drugs into the emulgel system; the first one is the hydrophobic, naturally occurring carotenoid Lutein; a known anti-aging skin supplement synthesized by green leafy plants. The second model is the hydrophilic ibuprofen; a well-known pain killer.
(4) Investigate the potential for controlled release, including kinetic studies in vitro.
(5) Develop an optimised gel in terms of drug loading and release.
(6) Test stability and toxicity of the gel-drug formulation in vitro.
(7) Results are expected be IP protected and/or published, as well as disseminated at national and international conferences. Through this process, we will seek stakeholder involvement from the pharmaceutical industry and we will target relevant funding bodies for bigger grants.

References

If you are interested in any of the above projects please contact the appropriate supervisor by email. For further details on the course and how to apply please visit https://www.lincoln.ac.uk/home/course/phrphrmr/.

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