About the Project
The calcium-binding protein S100P is overexpressed in a number of cancers, notably in the majority of cases of pancreatic adenocarcinoma, the most common and difficult-to-treat form of pancreatic cancer. This protein promotes tumour progression and metastasis through a number of pathways, making it an attractive prospect as a potential drug target.
The group has already discovered a number of functional small molecule S100P inhibitors that reduce cell invasiveness [1, 2], and have identified further S100P-binding molecular fragments through biophysical screening techniques. The next phase of the project focuses on optimising the activity and selectivity of inhibitors to move towards potential drug candidates.
The successful PhD candidate will undertake computational modelling and synthesis of novel small molecule inhibitors, taking these forward for formulation and cell-based assays of targeted drug delivery.
Essential: The applicant must hold, or be about to attain, a first class or upper second-class (2:1) Honours degree or equivalent from a recognised institution, in the area of chemistry, pharmaceutical sciences, biochemistry or similar subject with a substantial chemistry component.
IELTS 6.5 (or above with no less than 5.5 in any band)/TOEFL 79 (if international student).
Desirable: Previous experience of any aspect of drug discovery through employment, placement or project work would be an advantage.
Candidates with an enthusiasm for multidisciplinary drug discovery are encouraged to apply.
To apply, please download the application form from our website and send along with qualification certificates and/or university transcripts and a copy of your passport to: [Email Address Removed].
Due to the current pandemic, references should also be sent by email to [Email Address Removed].
2. Camara, R., Ogbeni, D, Gerstmann, L., Ostovar, M., Hurer, E., Scott, M., Mahmoud, N. G., Radon, T. P., Cronogorac-Jurcevic, T., Patel, P., Mackenzie, L. S., Chau, D. Y. C., Kirton, S. B. and Rossiter, S. (2020) European Journal of Medicinal Chemistry, In press.
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