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Designing Bioreactors for In Vitro Red Blood Cell Manufacture

Project Description

With an increasing global demand for blood units for transfusion, there is much interest in manufacturing red blood cells in vitro. However, current approaches for the in vitro manufacture of red blood cells from adult blood progenitor cells do not provide a cost-effective option. In this respect, there is a need for improved manufacturing designs to produce these cells at a clinically relevant scale.

The goal of this Ph.D. research is to design, develop and compare efficient bioreactor systems for expanding and differentiating erythroid progenitor cell in vitro. In this project the successful candidate will work on developing a fluidized bed bioreactor system for expanding and differentiating adult blood progenitor cells. The operating conditions for obtaining maximal expansion, differentiation with regards to the hydrodynamic parameters and cell viability/ differentiation will be optimized. In addition, the FBB’s performance in comparison to other bioreactor types including hollow fibre reactors and stirred tank reactors will be assessed. The candidate will gain training in a variety of topics and technologies including aseptic mammalian (stem) cell-culture, molecular and cell biology techniques, bioreactor design and economic costing studies. This doctoral project has a strong multidisciplinary nature and the candidate should have an interest in Stem Cell Biology and Bioprocessing Engineering. Hands-on training will be provided as appropriate to the project.

The successful applicant will be a part of the University of Bath’s newly established Centre for Integrated Bioprocessing Research unit. The project is also in close collaborations with the University of Bristol’s Blood and Transplant Research unit (

Science or Engineering applicants should ideally have graduated (or be due to graduate) with a Bachelor’s or Master’s first class degree and/or distinction (or equivalent overseas qualification) in Chemical engineering, Biomedical/Cell and Tissue Engineering or other relevant disciplines. Due to funding restrictions, only UK/EU applicants will be considered. English language requirements must be satisfied in advance of a funding offer.

Prospective candidates are encouraged to contact Dr Sandhya Moise () directly for further details. Please send a CV and a cover letter to Dr Moise. Candidates will be shortlisted for the full online application.

Formal applications should be made via the University of Bath’s online application form for a Ph.D. in Chemical Engineering. Please ensure that you state the full project title and lead supervisor name on the application form.

More information about applying for a PhD at Bath may be found here:

Anticipated start date: 30 September 2019

Funding Notes

This project is eligible for inclusion in funding rounds scheduled for February 2019, March 2019 and April 2019. A full application must have been submitted before inclusion in a funding round.
Funding will cover Home/EU tuition fees, a maintenance stipend (£14,777 pa (2018/19 rate)) and a training support fee of £1,000 per annum for 3.5 years. Early application is strongly recommended.
Candidates who can source their own funding are encouraged to apply.

How good is research at University of Bath in Aeronautical, Mechanical, Chemical and Manufacturing Engineering?

FTE Category A staff submitted: 61.00

Research output data provided by the Research Excellence Framework (REF)

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