This position will remain open until a suitable candidate is found. The Department of Chemistry at the University of Liverpool seeks applications for a post-graduate studentship leading to a PhD, starting September 2019 (or soon thereafter).
Targeted drug delivery offers the potential for considerable clinical benefit through the reduction of side effects and increases in the therapeutic efficacy. This may be achieved by using nanocarriers with appropriate particle properties to access specific biological compartments. Solid lipid nanoparticles (SLNs) are an example of such a technology platform. SLNs are nanocarriers with considerable promise; the biocompatibility and versatility of the lipid core avoids concerns over long term accumulation of the nanocarrier material. In this project, we will design, synthesise and characterise a modular SLN system. The analysis of the particles will be achieved by using our existing asymmetrical flow field-flow fractionation (AF4) equipment, a technique that separates nanoparticles based on their size and shape with high resolution. This student will then work alongside researchers in pharmacology student to evaluate the biological behaviour of the SLNs. This will provide the understanding necessary to allow SLNs to be tailored to deliver different drugs to different biological compartments.
This studentship will provide training in a wide range of areas including polymer synthesis/characterisation, nanoparticle preparation/analysis and the use of biological assays. Additionally, the student will gain extensive experience of conducting truly multidisciplinary research; such skills are becoming increase important in the modern research landscape. We seek highly motivated individuals with at least a 2.1 degree or equivalent in chemistry or materials science. Prior background knowledge in polymer chemistry and an interest in biomaterials would be an advantage. Informal enquiries should be addressed to Dr Tom McDonald by email [email protected].