About the Project
This research is based on a multi-disciplinary group from the Universities of Leicester, Strathclyde and Glasgow. This group brings together expertise in nano-engineering, bio-organic chemistry, photonics, structural biology, RNA splicing and molecular biology, and has been funded by a BBSRC sLOLA grant for 5 years. This PhD project is concerned with in vivo tests of the predictions from our in vitro results, and therefore provides a very important complement to the more biophysical work. It will involve the use of RNAi and over-expression, mutations and CLIP to test protein interactions in cells. More direct evidence will come from biotin proximity ligation assays, in vivo protein-protein interaction assays based on fluorescence microscopy and novel methods for targeting protein cross-linking to proteins on specific pre-mRNA substrates.
The University if Leicester is very well equipped for this research, with extensive conventional cell microscopy resources and expertise in cell and molecular biology in the supervisors’ labs.
UK/EU applicants only.
Applicants are required to hold/or expect to obtain a UK Bachelor Degree 2:1 or better in a relevant subject.
The University of Leicester English language requirements apply where applicable: https://le.ac.uk/study/research-degrees/entry-reqs/eng-lang-reqs
How to apply:
To apply for the PhD please refer to the guidelines and use the application link at https://le.ac.uk/study/research-degrees/funded-opportunities/bbsrc-mibtp
Please also submit your MIBTP notification form at https://warwick.ac.uk/fac/cross_fac/mibtp/pgstudy/phd_opportunities/application/
Project / Funding Enquiries: [Email Address Removed]
Application enquiries to [Email Address Removed]
UK/EU fees and stipend at UKRI rates. For 2020 this will be £15,285 pa
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