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Determination of cell populations necessary for effective action of receptor tyrosine kinase-like orphan receptor 1 bispecific antibody constructs in chronic lymphocytic leukaemia

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  • Full or part time
    Dr H Walter
    Prof M Dyer
    Dr S Jayne
  • Application Deadline
    No more applications being accepted
  • Competition Funded PhD Project (European/UK Students Only)
    Competition Funded PhD Project (European/UK Students Only)

Project Description

Although there have been spectacular improvements in the treatment of CLL in recent years, for patients who progress following targeted therapies, the prognosis remains poor with few available therapeutic options.

Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is a cell surface protein expressed in several haematological and solid tumour malignancies. In CLL, ROR1 is highly expressed and is thought to be important in promoting CLL survival and disease progression. Targeting this receptor therapeutically may therefore be important in the management of CLL.

The use of genetically modified T cells that express chimeric antigen receptors (CARs) shows great promise in the treatment of haematological malignancies. Bi-specific T cell engagers (BiTEs) are single chain antibody constructs, which do not require ex-vivo manipulation and engineering. They are formed from two single chain antibody derived variable fragments (scFv). ROR1 BiTEs consist of one arm which binds to ROR1 and the second to CD3+ effector cells, enabling recruitment of immune effector cells to the tumour environment.

We are seeking to determine the in vitro efficacy of ROR1 BiTEs in CLL. This proposal will characterise T cell populations in CLL necessary for efficacy of ROR1 BiTES, with the aim of identifying predictive biomarkers.

Entry requirements:
You must hold (or be about to obtain) a First or an Upper Second Class UK undergraduate degree or an equivalent degree from a recognised EU institution, in an area relevant to the projects you are applying for.

Qualifications (or a combination of qualifications and experience) which demonstrate equivalent ability and attainment will also be considered.

For example, a less than sufficient first degree may be enhanced to meet the requirements by the acquisition of a Distinction at Masters level or significant research experience gained from employment).

Informal enquiries:
If you have any questions or would like to find out more about IMPACT, please get in touch.
Email us at [Email Address Removed]

Eligibility:
UK/EU applicants only

To apply:
Please refer to https://more.bham.ac.uk/mrc-impact/phd-opportunities/

Funding Notes

The Studentship provides 3.5 years of Stipend at UKRI rates and Tuition fees at UK/EU rates.



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