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Determination of hyper-elasticity, viscoelasticity and anisotropy of ocular tissue


Project Description

This position will remain open until a suitable candidate has been found.

Most earlier research has relied on experimental tests, in which corneal buttons and scleral hemi-spheres were subjected to a variable internal (inflation) pressure while monitoring their deformation, and using the results in inverse analysis processes to determine the material properties of the tissue. While this work had been useful, it suffered from a number of fundamental problems including the introduction of non-physiologic boundary conditions along the edges of the cornea and sclera. In this research, we will test intact, whole ocular globes under physiologic loading and boundary conditions. A current inflation test rig will be further developed to enable measurement of behaviour with high accuracy, and hence determination of material properties of tissue with high reliability. The testing method will involve processing of digital images of the cornea before and during deformation, 3D digital image correlation, construction of numerical models, whose geometry matches that of test eye globes, and inverse analysis to determine the material properties in different parts of the globe. The results will be of huge benefit to current medical device development that rely on having accurate material behaviour patterns.

Funding Notes

Student will need to cover their own tuition fees and living expenses, research consumables costs will be covered by the research group.

References

Elsheikh, A., Geraghty, B., Rama, P., Campanelli, M. and Meek, K.M., 2010. Characterization of age-related variation in corneal biomechanical properties. Journal of the Royal Society Interface, p.rsif20100108.
Elsheikh, A., Alhasso, D. and Rama, P., 2008. Assessment of the epithelium's contribution to corneal biomechanics. Experimental eye research, 86(2), pp.445-451.
Elsheikh, A., Wang, D., Brown, M., Rama, P., Campanelli, M. and Pye, D., 2007. Assessment of corneal biomechanical properties and their variation with age. Current eye research, 32(1), pp.11-19.
Elsheikh, A., Alhasso, D. and Rama, P., 2008. Biomechanical properties of human and porcine corneas. Experimental eye research, 86(5), pp.783-790.
Elsheikh, A., Geraghty, B., Alhasso, D., Knappett, J., Campanelli, M. and Rama, P., 2010. Regional variation in the biomechanical properties of the human sclera. Experimental eye research, 90(5), pp.624-633.
Geraghty, B., Jones, S.W., Rama, P., Akhtar, R. and Elsheikh, A., 2012. Age-related variations in the biomechanical properties of human sclera. Journal of the mechanical behavior of biomedical materials, 16, pp.181-191.
Elsheikh, A., Geraghty, B., Alhasso, D., Knappett, J., Campanelli, M. and Rama, P., 2010. Regional variation in the biomechanical properties of the human sclera. Experimental eye research, 90(5), pp.624-633.

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