About the Project
Techniques and Methodology
Proteomic analysis, protein purification, mass spectrometry, SDS-PAGE.
Impact on Alzheimer’s research
How brain protein O-GlcNAcylation changes as we age has yet to be determined and there is no consensus about what alterations occur in AD. Protein O-GlcNAcylation is a poorly understood protein post-translational modification although its dysregulation has been identified in a number of other diseases. This research will identify the spectrum of changes in brain protein O-GlcNAcylation that occurs as we age and as AD progresses. It will identify key proteins that distinguish between ageing and Alzheimer’s disease and providing a basis for accelerating new therapeutic agents to combat Alzheimer’s.
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