About the Project
In the second project, we collated data on AMR between 2013 and 2017 from the records of the Northern and Southern central hospitals in Cape Verde. We observed an increase in resistance levels of Staphylococcus aureus strains throughout the years across the archipelago in Cape Verde. S. aureus is a common colonizer of the anterior nares of the nose, the skin and of other mucosa; but S. aureus strains can cause important infections in the community and in the hospital. We have found a lineage in S. aureus with a unique pattern of antibiotic resistance.
To evaluate the origin and molecular evolution of AMR in H. pylori and S. aureus in Cape Verde, we have obtained whole-genome sequences of both susceptible and resistant strains. The specific objectives are:
1. To perform genome-wide association analyses to identify new genetic variants and genes associated with differences of susceptibility to antibiotics in H. pylori. The resistance patterns observed are not fully explained by resistance variants already described. The dataset composed by >220 sequenced strains characterized for antibiotic resistance levels will allow to perform phenotype-genotype correlations and to evaluate the genetic architecture of AMR in H. pylori in Cape Verde.
2. To identify the genetic elements that give rise to both the common and unique pattern of antibiotic resistance in S. aureus in Cape Verde. To annotate known genetic variants of resistance and to perform genome-wide analyses of the diversity of the resistant strains.
3. To evaluate the genetic diversity and evolution of H. pylori and S. aureus strains across the Cape Verde. To characterize the genetic variation and to perform population genetics analyses in both susceptible and resistant strains to evaluate the role of the population history (serial founder effects) of the archipelago and of the action of the antibiotic selective pressure in the distribution of the genetic diversity of H. pylori and S. aureus strains across the archipelago.
To understand within-the-host evolution of AMR in H. pylori. To characterize the genetic variation and to perform population genetics analyses of strains with different AMR patterns colonizing the same stomach.
UK/EU applicants only.
Applicants are required to hold/or expect to obtain a UK Bachelor Degree 2:1 or better in a relevant subject.
The University of Leicester English language requirements apply where applicable: https://le.ac.uk/study/research-degrees/entry-reqs/eng-lang-reqs/ielts-65
How to apply:
To apply for the PhD please refer to the guidelines and use the application link at https://le.ac.uk/study/research-degrees/funded-opportunities/bbsrc-mibtp
Please also submit your MIBTP notification form at https://warwick.ac.uk/fac/cross_fac/mibtp/pgstudy/phd_opportunities/application/
Project / Funding Enquiries: [Email Address Removed]
Application enquiries to [Email Address Removed]
UK/EU fees and stipend at UKRI rates. For 2020 this will be £15,285 pa
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