About the Project
This project will address the issue of poor intra-tumoural delivery though the development of a novel controlled release (CR) platform, impregnated with RALA/AuNP. Using materials such as biodegradable hydrogels or electrospun nano-fibres, the appointed student will characterise RALA/AuNP loading and release rates, aiming to achieve release characteristics that align with clinical radiotherapy treatment plans. Furthermore, the student will undertake a range of established in vitro and in vivo cell and molecular biology based assays to established the effectiveness of the released nanoparticles as effective anti-cancer agents.
This projects forms part of an exciting collaborative partnership between Dr Jonathan Coulter, a prostate cancer expert in translational medicine and Professor McCarthy, a nucleic acids drug delivery expert and CEO of Phion Therapeutics.
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