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Developing a proteomic signature for the early detection of heart failure in diabetes

Project Description

Heart Failure has emerged as the commonest and deadliest complication of diabetes. Younger adults who develop diabetes have the highest life-time risk of heart failure and the excess risk is not attenuated by control of conventional cardiovascular risk factors. Professor McCann has been funded by a NIHR Research Professorship to develop a clinical risk score for the detection of early heart failure in asymptomatic people with type 2 diabetes. During the course of the next 3 years 500 patients will be recruited and undergo extensive imaging with cardiac MRI and all participants provide a blood sample.

In this PhD you will undertake analysis of the plasma samples in the laboratory of Professor Leong Ng. Initially you will do a detailed discovery set to identify candidate markers that distinguish those with and without early heart failure. This signature will then be tested in the entire cohort and validated using data from UK Biobank and external collaborators with similar cohorts of subjects.

The PhD studentship offers training in a wide variety of specialised techniques using state of the art instrumentation, including ion mobility (high definition) mass spectrometry, selected or parallel reaction monitoring, and use of statistical and bioinformatics programs to analyse big data.

Entry requirements

UK Bachelor Degree with at least 2:1 in a relevant subject or overseas equivalent.

University of Leicester English language requirements apply (where applicable).

Informal enquiries

Prof Leong Ng -

Prof Gerry McCann -

How to apply

Please refer to:

Eligibility: UK/EU applicants only

Funding Notes

3 year Studentship provides

• Annual stipend at UKRI rates

• UK/EU tuition fee waiver

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